ID A0A2J8WP88_PONAB Unreviewed; 86 AA.
AC A0A2J8WP88; A0A8I5UAJ7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=Iron-sulfur cluster assembly 1 homolog, mitochondrial {ECO:0000256|ARBA:ARBA00039743};
DE AltName: Full=HESB-like domain-containing protein 2 {ECO:0000256|ARBA:ARBA00042131};
DE AltName: Full=Iron-sulfur assembly protein IscA {ECO:0000256|ARBA:ARBA00042982};
GN Name=ISCA1 {ECO:0000313|Ensembl:ENSPPYP00000044669.1};
GN ORFNames=CR201_G0009064 {ECO:0000313|EMBL:PNJ71586.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|EMBL:PNJ71586.1};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000044669.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ71586.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ71586.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000044669.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins
CC functioning late in the iron-sulfur cluster assembly pathway. Probably
CC involved in the binding of an intermediate of Fe/S cluster assembly.
CC {ECO:0000256|ARBA:ARBA00037081}.
CC -!- SUBUNIT: Interacts with CRY2, but not with CRY1 (in vitro).
CC {ECO:0000256|ARBA:ARBA00038528}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family.
CC {ECO:0000256|ARBA:ARBA00006718}.
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DR EMBL; NDHI03003383; PNJ71586.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J8WP88; -.
DR Ensembl; ENSPPYT00000036981.1; ENSPPYP00000044669.1; ENSPPYG00000019339.3.
DR GeneTree; ENSGT00490000043385; -.
DR Proteomes; UP000001595; Chromosome 9.
DR GO; GO:0005739; C:mitochondrion; IEA:TreeGrafter.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:TreeGrafter.
DR Gene3D; 2.60.300.12; HesB-like domain; 1.
DR InterPro; IPR000361; ATAP_core_dom.
DR InterPro; IPR050322; Fe-S_cluster_asmbl/transfer.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR PANTHER; PTHR10072:SF41; IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR10072; IRON-SULFUR CLUSTER ASSEMBLY PROTEIN; 1.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; HesB-like domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 25..81
FT /note="Core"
FT /evidence="ECO:0000259|Pfam:PF01521"
SQ SEQUENCE 86 AA; 9368 MW; D9CD92B712DC37A2 CRC64;
MSASLVRATV RAVSKRKLQP TRAALTLTPS AVNKIKQLLK DKPEHVGVKV GVRTRGCNGL
SYTLEYTKTK GDSDEEVIQD AWSAVV
//
