ID A0A2K3DQE4_CHLRE Unreviewed; 574 AA.
AC A0A2K3DQE4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE RecName: Full=DNA primase large subunit C-terminal domain-containing protein {ECO:0000259|Pfam:PF04104};
GN ORFNames=CHLRE_06g293000v5 {ECO:0000313|EMBL:PNW82762.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055 {ECO:0000313|EMBL:PNW82762.1, ECO:0000313|Proteomes:UP000006906};
RN [1] {ECO:0000313|EMBL:PNW82762.1, ECO:0000313|Proteomes:UP000006906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503 {ECO:0000313|Proteomes:UP000006906};
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the eukaryotic-type primase large subunit
CC family. {ECO:0000256|ARBA:ARBA00010564}.
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DR EMBL; CM008967; PNW82762.1; -; Genomic_DNA.
DR RefSeq; XP_042924160.1; XM_043063454.1.
DR AlphaFoldDB; A0A2K3DQE4; -.
DR FunCoup; A0A2K3DQE4; 1787.
DR STRING; 3055.A0A2K3DQE4; -.
DR PaxDb; 3055-EDO97358; -.
DR GeneID; 5727120; -.
DR Gramene; PNW82762; PNW82762; CHLRE_06g293000v5.
DR KEGG; cre:CHLRE_06g293000v5; -.
DR InParanoid; A0A2K3DQE4; -.
DR OMA; RINYKPW; -.
DR OrthoDB; 421393at2759; -.
DR Proteomes; UP000006906; Chromosome 6.
DR ExpressionAtlas; A0A2K3DQE4; baseline.
DR GO; GO:0005658; C:alpha DNA polymerase:primase complex; IBA:GO_Central.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0006269; P:DNA replication, synthesis of primer; IBA:GO_Central.
DR CDD; cd07322; PriL_PriS_Eukaryotic; 1.
DR Gene3D; 1.20.930.80; -; 1.
DR InterPro; IPR058560; DNA_primase_C.
DR InterPro; IPR016558; DNA_primase_lsu_euk.
DR InterPro; IPR007238; DNA_primase_lsu_euk/arc.
DR PANTHER; PTHR10537; DNA PRIMASE LARGE SUBUNIT; 1.
DR PANTHER; PTHR10537:SF3; DNA PRIMASE LARGE SUBUNIT; 1.
DR Pfam; PF04104; DNA_primase_lrg; 1.
DR Pfam; PF26466; DNA_primase_lrg_N; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Primosome {ECO:0000256|ARBA:ARBA00022515};
KW Reference proteome {ECO:0000313|Proteomes:UP000006906}.
FT DOMAIN 335..503
FT /note="DNA primase large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04104"
FT REGION 543..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..552
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 62783 MW; 60B75280D296EEA1 CRC64;
MQFLATTKPG AAEFTSQLGG NAARKGNERM FSDLSMYSTP PSENITLEEF ERLALARLSV
LKEMEAYRLR HSNKTEKEYL DKLNQLKQKH MKGLTASAAA AAAAAGASGA AATSAAREEE
VRADNISHYV LRLAYCRTAE LRKWFLVQEC EMFRLKFGMY SAQEHEDFLS EHAPQYKLVP
HAELLSVRDA IVKVMRSNLE TREAISRVEN FGRDDADAKS KGPRSTADAR ELEPKFYKVA
WTLVPELVSQ RRVLLRGGWA YVSREALAPL VVAEFRTGVS RGLSEMARRW RQMFPAEEEQ
RLQPLVASLT NRSLVADYSG VATRYGDVSA ANLPQVAARH FPLCMGHLVS QLAAERHLRH
GGRQQLGLFL KGIGLPMEEA LVFWRSMFAP RCTGEAFDKQ YAYNIRHNYG REGKRTDYTA
HKCTTIVGSS GGPGDHHGCP YRRLDESALR AALGRLKCDD RKVEEAVSKA RDGHYQLACA
AAFEGVHRVP EMDVGISAPL QYYAESRRIC AERESAAVQG AAAAATEAAA AAATAATAAD
AGGDPAAAAA ADAGKEQRGV KRAAAGDSTP GAAR
//
