ID A0A2K5CHM0_AOTNA Unreviewed; 738 AA.
AC A0A2K5CHM0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 10-JUN-2026, entry version 36.
DE RecName: Full=Rho GTPase-activating protein SYDE1 {ECO:0000256|ARBA:ARBA00074687};
DE AltName: Full=Synapse defective protein 1 homolog 1 {ECO:0000256|ARBA:ARBA00075368};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000008154.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000008154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases. As a GCM1
CC downstream effector, it is involved in placental development and
CC positively regulates trophoblast cells migration. It regulates
CC cytoskeletal remodeling by controlling the activity of Rho GTPases
CC including RHOA, CDC42 and RAC1. {ECO:0000256|ARBA:ARBA00057607}.
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DR AlphaFoldDB; A0A2K5CHM0; -.
DR STRING; 37293.ENSANAP00000008154; -.
DR Ensembl; ENSANAT00000025934.1; ENSANAP00000008154.1; ENSANAG00000022113.1.
DR GeneTree; ENSGT01030000234635; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0097060; C:synaptic membrane; IEA:TreeGrafter.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR GO; GO:1901165; P:positive regulation of trophoblast cell migration; IEA:Ensembl.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR FunFam; 1.10.555.10:FF:000051; Synapse defective Rho GTPase homolog 1; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR052118; Rho-GAP_regulator.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR057459; SYDE1/2_C2.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF2; RHO GTPASE-ACTIVATING PROTEIN SYDE1; 1.
DR Pfam; PF25336; C2_SYDE; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00172}; Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 252..369
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 401..607
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..74
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..134
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..150
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..224
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 80058 MW; 3862ABB184702EF5 CRC64;
MAEPLLRKTF SRLRGREKLP RKKSDAKERG ERGSVREEGS PSPARPRRPR GRSAGRSGGG
SPSPEASRSP ARGAYLQSLE PSSRRWVLGG AKPTEDTSLG PGAPGSGEPA GEIWYNPIPE
EDPKPPASEP PGPQPDSAEP EGPASQGAAP ASPPTKASRT KSPGPARRLS IKMKKLPELR
RRLSLRGPRA GRERERAAPA GSVISRYHLD SSVGGPGRAA GSGGTQSPRT GYLSDGDSPE
RPAGLPSPTS FQPYEVGPTA RAPPAALWGR LSLHLYGLGG LRPAPGATPR DLCCLLQVDG
EARARTGPLR GGPDFLRLDH TFHLELEAAQ LLRALVLAWD PGVRRHRPCA QGTVLLPTVF
RGCQAQQLAV RLEPQGLLYA KLTLSEQQEA PATAEPRVFG LPLPLLVERE RPPGQVPLII
QKCVGQIERR GLRVVGLYRL CGSAAVKKEL RDAFERDSAA VCLSEDLYPD INVITGILKD
YLRELPTPLI TQPLYQVVLE AMAHDPPNRG PPTTDSTRGL LSCLPDVERA TLTLLLDHLR
LVSSFHAYNR MTPQNLAVCF GPVLLPARQA PTRSRARSSG PGLTSAVDFK RHIEVLHYLL
QSWPDPHLPP EAPDVAPYLR PKRQPALHLP LADPEVVSRP RGRGGPESPP SNRYAGDWSV
CGRDFLPCGR DFLSGPDYDH VTGSDSEDED EEAGEPRITA DFEDDFDAPF NPHLNLKDFD
ALILDLEREL SKQINVCL
//
