ID A0A2K5D466_AOTNA Unreviewed; 503 AA.
AC A0A2K5D466;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 28-JAN-2026, entry version 31.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000015746.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000015746.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSANAP00000015746.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR AlphaFoldDB; A0A2K5D466; -.
DR STRING; 37293.ENSANAP00000015746; -.
DR Ensembl; ENSANAT00000033588.1; ENSANAP00000015746.1; ENSANAG00000025758.1.
DR GeneTree; ENSGT00940000159000; -.
DR OMA; RAAICCW; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 367..461
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 100..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 57539 MW; ACFA6145CDFB2930 CRC64;
IDKVGKMWNN FKYRCQNLFS HEGVSHNENV DMNSNRCLSV KEKNISIGDS TPQQQSSPLR
ENTALELGLS PSKNSSGRNQ NCATEIPQIV EISIEKDNDS CVTPGTRLTQ RDSYSRHKKH
SCSTKTQSSL DTDKKFGRTR SGLQRRERRY GVSSVHDMDS VSSRIVGSHS LRQQLQDTVG
FKQSKPLFSN KRKIHLSELM LEKCPFHAGS DLAQKWHLIK QHTAPVSPHS TFFDTFDPSL
VSTEDEEDRL RERRWLSIEE GVDPPPNAQI HTFEATEQVN PLYKLGPKLA PGMTEISGDS
SAIPQANCDS EEDATTLCLQ SQRQKQHQVS GDSHTHVSRQ GAWKVHTQID YIHCLVPDLL
QITGNPCYWG VMDCYEAEAL LEGKPEGTFL LRDSAQEDYL FSVSFRHHNR SLHARIEQWN
HNFSFDAHDP CVFHSSTVTG LLEHYKDPSS CMFFEPLTFP FSLQYICRAV ICRCTTYDDF
LKEYHYKQRV RVCWLEREPV KAK
//
