ID   A0A2K5TVK3_MACFA        Unreviewed;       842 AA.
AC   A0A2K5TVK3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   28-JAN-2026, entry version 34.
DE   SubName: Full=Zinc finger protein 598, E3 ubiquitin ligase {ECO:0000313|Ensembl:ENSMFAP00000004102.2};
GN   Name=ZNF598 {ECO:0000313|Ensembl:ENSMFAP00000004102.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000004102.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000004102.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000004102.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSMFAP00000004102.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5TVK3; -.
DR   STRING; 9541.ENSMFAP00000004102; -.
DR   Ensembl; ENSMFAT00000022763.2; ENSMFAP00000004102.2; ENSMFAG00000001763.2.
DR   VEuPathDB; HostDB:ENSMFAG00000001763; -.
DR   GeneTree; ENSGT00390000014178; -.
DR   Proteomes; UP000233100; Chromosome 20.
DR   Bgee; ENSMFAG00000001763; Expressed in cerebellum and 13 other cell types or tissues.
DR   GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:TreeGrafter.
DR   GO; GO:0072344; P:rescue of stalled ribosome; IEA:InterPro.
DR   InterPro; IPR057634; PAH_ZNF598/HEL2.
DR   InterPro; IPR056437; Znf-C2H2_ZNF598/HEL2.
DR   InterPro; IPR044288; ZNF598/HEL2.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR059042; Znf_C2H2_ZNF598.
DR   PANTHER; PTHR22938:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZNF598; 1.
DR   PANTHER; PTHR22938; ZINC FINGER PROTEIN 598; 1.
DR   Pfam; PF23202; PAH_ZNF598; 1.
DR   Pfam; PF25447; RING_ZNF598; 1.
DR   Pfam; PF23230; zf-C2H2_13; 1.
DR   Pfam; PF23208; zf_C2H2_ZNF598; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT   DOMAIN          134..155
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS00028"
FT   REGION          225..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          432..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..303
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..333
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..485
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..516
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        545..555
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   842 AA;  92754 MW;  8BF4632876E57F97 CRC64;
     MRVLCEQRYC AVCREELRQV VFGKKLPAFA TIPIHQLQHE KKYDIYFADG KVYALYRQLL
     QHECPRCPEL PPFSLFGDLE QHMRRQHELF CCRLCLQHLQ IFTYERKWYS RKDLARHRMQ
     GDPDDTSHRG HPLCKFCDER YLDNDELLKH LRRDHYFCHF CDSDGAQDYY SDYAYLREHF
     REKHFLCEEG RCSTEQFTHA FRTEIDLKAH RTACHSRSRA EARQNRQIDL QFSYAPRHSR
     RNEGVVGGED YEEVDRYSRQ GRVARAGTRG AQQSRRGSWR YKREEEDREV AAAVRASVAA
     QQQEEARRSE DREEGGRPKK EEAAVRGPEE PRGPRRPPRT QGEGPGPKET STNGPVSQEA
     FPVTGPATPW CVGTLPPPSP KLKDEDFPSL SASTSSCCST AAVPGPVGLA LPYAIPARGR
     SAFQEEDFPA LVSSVPKPGT TPTSLVSAWN SSSSGKKVAQ PPPSAQATGS GQPTRKAGKG
     SRGGRKGGPP LTQEEEGGSP AAQELLSTRP TGSISSPLGP VSIQPSKVGK KKKVGSEKPG
     TTLPQPLPAS CPPGPMQALE APASRAEGPV AVVVNGHTEG PAPARSAPKE PPGLPRPLGS
     FPCPTPQEDF PALGGPCPPR MPPPPGFSAV VLLKGTPPPP PPGLVPVSKP PGFSGLLPGP
     HPACVPSPTT TTTTKPPRPP PALQAYLVPE NFRERNLQLI QSIRDFLQSD EARFSEFKSH
     SGEFRGLISA AQYYKSCRDL LGENFQKVFN ELLVLLPDTA KQQELLSAHT DFCNRDKPLG
     TKSKKNKKSA WQVTTQQAGL DCRVCPTCQQ VLAHGDASSH QALHAARDDD FPSLQAIARI
     IT
//