ID A0A2K5YEL0_MANLE Unreviewed; 977 AA.
AC A0A2K5YEL0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 28-JAN-2026, entry version 38.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit alpha {ECO:0000256|RuleBase:RU362084};
GN Name=ATP12A {ECO:0000313|Ensembl:ENSMLEP00000014002.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000014002.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000014002.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSMLEP00000014002.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=K(+)(out) + ATP + H2O + H(+)(in) = K(+)(in) + ADP + phosphate
CC + 2 H(+)(out); Xref=Rhea:RHEA:22044, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.19;
CC Evidence={ECO:0000256|ARBA:ARBA00047839};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22045;
CC Evidence={ECO:0000256|ARBA:ARBA00047839};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362084};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIC subfamily. {ECO:0000256|ARBA:ARBA00006934,
CC ECO:0000256|RuleBase:RU362084}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362084}.
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DR AlphaFoldDB; A0A2K5YEL0; -.
DR Ensembl; ENSMLET00000037445.1; ENSMLEP00000014002.1; ENSMLEG00000031149.1.
DR GeneTree; ENSGT00940000159259; -.
DR OMA; MFFLYMW; -.
DR Proteomes; UP000233140; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008900; F:P-type potassium:proton transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IEA:TreeGrafter.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:TreeGrafter.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:TreeGrafter.
DR FunFam; 1.20.1110.10:FF:000079; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR FunFam; 2.70.150.10:FF:000003; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR FunFam; 3.40.1110.10:FF:000001; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR FunFam; 3.40.50.1000:FF:000083; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR FunFam; 1.20.1110.10:FF:000095; Sodium/potassium-transporting ATPase subunit alpha-1; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 2.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR050510; Cation_transp_ATPase_P-type.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR005775; P-type_ATPase_IIC.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01106; ATPase-IIC_X-K; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR43294:SF1; POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 2; 1.
DR PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF08282; Hydrolase_3; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00121; NAKATPASE.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362084};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362084}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362084};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362084};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362084};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU362084};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW ECO:0000256|RuleBase:RU362084};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362084};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362084};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362084}.
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 303..327
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 333..356
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 798..825
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 869..888
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 908..927
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT DOMAIN 54..128
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
SQ SEQUENCE 977 AA; 108595 MW; 8DF3AFEB2C2B3CC5 CRC64;
QTPEIYSVEL SGTKDIVKTD KGDGKEKYRG LKKNCLERKK KNHKEEFQKE LHLDDHKLSN
RELEKKYGTD IITGLSSTRA AELLARDGPN SLTPPKQTPE IVKFLKQMVG GFSVLLWVGA
FLCWIAFGIE YSSNKSASLN NVYLGSVLVL VVIFTGIFAY YQEAKSTNIM SSFKKMIPQQ
ALVIRDSEKK TIPSEQLVVG DIVEVKGGDQ IPADIRVLSS QGCRVDNSSL TGESEPQPRS
SEFTHENPLE TKNICFYSTT CLEGTITGMV INTGDRTIIG HIASLASGVG NEKTPIAIEI
EHFVHIVAGV AVSIGILFFI IAVSMNYRVL DSIIFLIGII VANVPEGLLA TVTVTLSLTA
KRMAKKNCLV KNLEAVETLG STSIICSDKT GTLTQNRMTV AHLWFDNQIF VADTSENHSS
QVFDQSSRTW ASLSKIITLC NRAEFKPGQE NVPIMKKAVI GDASETALLK FSEVILGDVM
EIRKRNRKVA EIPFNSTNKF QLSIHETDDP HDKRFLMVMK GAPERILEKC STIMISGEEH
PLDESTAKAF HTAYMELGGL GERVLVIMVT GDHPITAKAI AKSVGIISAN SETVEDIARR
LNIAVEQVNK WDAKAAVVTG MELKDMSSEQ VDEILANYQE IVFARTSPQQ KLIIVEGCQR
QDAVVAVTGD GVNDSPALKK ADIGVAMGIA GSDAAKNAAD MVLLDDNFAS IVTGVEEGRL
IFDNLKKTIA YTLTKNIAEL CPFLIYIIVG LPLPIGTITI LFIDLGTDII PSIALAYEKA
ESDIMNRKPR HKKKDRLVNQ PLAVYSYLHI GLMQALGAFL VYFTVYAQEG FLPRSLINLR
VEWEKDYVND LEDSYGQEWT RYQRAYLEWT GYTAFFVGIL VQQIADLIIR KTRRNSIFQQ
GPFRNKVIWV GIASQIVIGL VLSYGLGSVT ALSFTMLRAQ YWFVAVPHAI LIWVYDEVRK
LFIRLYPGSW WDKNMYY
//
