ID A0A2K6A8A2_MANLE Unreviewed; 555 AA.
AC A0A2K6A8A2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 28-JAN-2026, entry version 42.
DE SubName: Full=SP140 nuclear body protein like {ECO:0000313|Ensembl:ENSMLEP00000036285.1};
GN Name=SP140L {ECO:0000313|Ensembl:ENSMLEP00000036285.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000036285.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000036285.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSMLEP00000036285.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR AlphaFoldDB; A0A2K6A8A2; -.
DR Ensembl; ENSMLET00000059886.1; ENSMLEP00000036285.1; ENSMLEG00000042246.1.
DR GeneTree; ENSGT00940000164523; -.
DR OMA; CMENPQT; -.
DR Proteomes; UP000233140; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-ARBA.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-ARBA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-ARBA.
DR CDD; cd05501; Bromo_SP100C_like; 1.
DR CDD; cd15626; PHD_SP110_140; 1.
DR FunFam; 1.20.920.10:FF:000028; Nuclear autoantigen Sp-100; 1.
DR FunFam; 3.30.40.10:FF:000294; Nuclear autoantigen Sp-100; 1.
DR FunFam; 3.10.390.10:FF:000005; SP140 nuclear body protein; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR004865; HSR_dom.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR000770; SAND_dom.
DR InterPro; IPR043563; Sp110/Sp140/Sp140L-like.
DR InterPro; IPR030411; Sp140_Bromo.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46386; NUCLEAR BODY PROTEIN SP140; 1.
DR PANTHER; PTHR46386:SF1; NUCLEAR BODY PROTEIN SP140-LIKE PROTEIN; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF03172; HSR; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF01342; SAND; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00258; SAND; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51414; HSR; 1.
DR PROSITE; PS50864; SAND; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 8..124
FT /note="HSR"
FT /evidence="ECO:0000259|PROSITE:PS51414"
FT DOMAIN 268..349
FT /note="SAND"
FT /evidence="ECO:0000259|PROSITE:PS50864"
FT DOMAIN 378..424
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 483..517
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 130..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..196
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..265
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 64019 MW; F9F1B48DCFD75F71 CRC64;
MAGGGSDLST RIFTEDQDVD EGLLYDTIFK HFKRHKLEIS NAIKKTFPFL EGLRDRELIT
DKMFEDSQDS CRNLVPVQRV VYNVLSELEK TFNLPVLEAL FSEVNMQEYP DLIHIRKSFN
NAIQDKLSFQ ESDRKEREER PDIQLSLEQE EVPESPEAKM ENGQACGKMD TVGIGNNSTL
EKPKRKRKKK KGHSWTRIKS GTQKKIQQHD NSKPGGQLVP NEEKAKVNLQ GLSKISGSKR
SKPGTRFTQS DRAPQKRVRS RASRKHKDET VGFQAPLLPV TCGGVKGILH KEKLKQGSFL
KCIQTEDGNW FTPGEFETKG GYARAKNWKL SVRCGGRPLQ RLIEEGSLPN PPKIHYRNQK
RILKSHNNSS VDPCMRNLDE CEVCRDGGEL FCCDTCSRVF HEDCHIAPVE TERTPWSCIF
CRMKESSGSQ QCCQESEVLE RQMCPQEQLK CEFLLLKVYC CSESSFFAKI PYYYYIREAC
QGLKEPMWLD KIKKRLNEHS YPQVEGFIRD MRLIFQNHRA SYKYNDFGQM GLRLEAEFEK
DFKEVFAIQE TNGNS
//
