ID   A0A2K6QJ14_RHIRO        Unreviewed;       685 AA.
AC   A0A2K6QJ14;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   28-JAN-2026, entry version 38.
DE   SubName: Full=G protein signaling modulator 2 {ECO:0000313|Ensembl:ENSRROP00000028769.1};
GN   Name=GPSM2 {ECO:0000313|Ensembl:ENSRROP00000028769.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000028769.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000028769.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSRROP00000028769.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the GPSM family.
CC       {ECO:0000256|ARBA:ARBA00006600}.
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DR   RefSeq; XP_010371178.1; XM_010372876.2.
DR   RefSeq; XP_010371186.1; XM_010372884.2.
DR   AlphaFoldDB; A0A2K6QJ14; -.
DR   STRING; 61622.ENSRROP00000028769; -.
DR   Ensembl; ENSRROT00000053143.1; ENSRROP00000028769.1; ENSRROG00000038177.1.
DR   GeneID; 104669785; -.
DR   KEGG; rro:104669785; -.
DR   CTD; 29899; -.
DR   GeneTree; ENSGT00940000161257; -.
DR   OMA; NQSVLGH; -.
DR   OrthoDB; 286233at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0097575; C:lateral cell cortex; IEA:Ensembl.
DR   GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:Ensembl.
DR   GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR   GO; GO:0051661; P:maintenance of centrosome location; IEA:Ensembl.
DR   GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR   GO; GO:1904778; P:positive regulation of protein localization to cell cortex; IEA:Ensembl.
DR   GO; GO:1905832; P:positive regulation of spindle assembly; IEA:Ensembl.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; IEA:Ensembl.
DR   GO; GO:0009642; P:response to light intensity; IEA:Ensembl.
DR   FunFam; 1.25.40.10:FF:000192; G-protein-signaling modulator 1 isoform a; 1.
DR   FunFam; 1.25.40.10:FF:000043; G-protein-signaling modulator 2 isoform X1; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR003109; GoLoco_motif.
DR   InterPro; IPR052386; GPSM.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_rpt.
DR   PANTHER; PTHR45954:SF3; G-PROTEIN-SIGNALING MODULATOR 2; 1.
DR   PANTHER; PTHR45954; LD33695P; 1.
DR   Pfam; PF02188; GoLoco; 4.
DR   Pfam; PF13374; TPR_10; 1.
DR   Pfam; PF13424; TPR_12; 2.
DR   Pfam; PF13176; TPR_7; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00390; GoLoco; 4.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50877; GOLOCO; 4.
DR   PROSITE; PS50005; TPR; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}.
FT   REPEAT          62..95
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          242..275
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   685 AA;  76735 MW;  D5F55143EC4FC8E5 CRC64;
     MEENLISMRE DHSFHVRYRM EASCLELALE GERLCKSGDC RAGVSFFEAA VQVGTEDLKT
     LSAIYSQLGN AYFYLHDYAK ALEYHHHDLT LARTIGDQLG EAKASGNLGN TLKVLGNFDE
     AIVCCQRHLD ISRELNDKVG EARALYNLGN VYHAKGKSFG YPGPQDVGEF PEEVTDALQA
     AVDFYEENLS LVTALGDRAA QGRAFGNLGN THYLLGNFRD AVIAHEQRLL IAKEFGDKAA
     ERRAYSNLGN AYIFLGEFET ASEYYKKTLL LARQLKDRAV EAQSCYSLGN TYTLLQDYEK
     AIDYHLKHLA IAQELNDRIG EGRACWSLGN AYTALGNHDQ AMHFAEKHLE ISREVGDKSG
     ELTARLNLSD LQMVLGLSYS TNNSIMSENT EIDSSLNGVR PKLGRRHSME NMELMKLTPE
     KIQNWNSEIL AKQKPLIAKP SAKLLFVNRL KGKKYKTNSS TKVLQDASNS IDHRIPDSQR
     KISADTIGDE GFFDLLSRFQ SNRMDDQRCC LQEKNCHTAS TTTSSTPPKM MLKTPSVPVV
     SPNTDEFLDL LASSQSRRLD DQRASFSNLP GLRLTQNNSQ SVLSHLMTNG NKEADEDFFD
     ILVKCQGSRL DDQRCAPPPA TTKGPTVPDE DFFSLILRSQ AKRMDEQRVL LQRDQNRDTD
     FGLKDFLQSN ALLEFKNSGK KSADH
//