ID A0A2K6RE75_RHIRO Unreviewed; 340 AA.
AC A0A2K6RE75;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 28-JAN-2026, entry version 43.
DE RecName: Full=Meiotic recombination protein {ECO:0000256|PIRNR:PIRNR005856};
GN Name=DMC1 {ECO:0000313|Ensembl:ENSRROP00000039353.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000039353.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000039353.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSRROP00000039353.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: May participate in meiotic recombination, specifically in
CC homologous strand assimilation, which is required for the resolution of
CC meiotic double-strand breaks. {ECO:0000256|PIRNR:PIRNR005856}.
CC -!- FUNCTION: Participates in meiotic recombination, specifically in
CC homologous strand assimilation, which is required for the resolution of
CC meiotic double-strand breaks. {ECO:0000256|ARBA:ARBA00056818}.
CC -!- SUBUNIT: Double stacked ring-shaped homooctamer. Interacts with BRCA2.
CC Interacts with the MND1-PSMC3IP heterodimer. Interacts with RAD51AP1;
CC the interaction is direct and stimulates DMC1-mediated homologous
CC recombination. {ECO:0000256|ARBA:ARBA00064395}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SIMILARITY: Belongs to the RecA family. DMC1 subfamily.
CC {ECO:0000256|ARBA:ARBA00008897, ECO:0000256|PIRNR:PIRNR005856}.
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DR RefSeq; XP_030771313.1; XM_030915453.1.
DR AlphaFoldDB; A0A2K6RE75; -.
DR STRING; 61622.ENSRROP00000039353; -.
DR Ensembl; ENSRROT00000063834.1; ENSRROP00000039353.1; ENSRROG00000043002.1.
DR GeneID; 104682539; -.
DR CTD; 11144; -.
DR GeneTree; ENSGT00760000119398; -.
DR OMA; ANPMKPV; -.
DR OrthoDB; 10251254at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0000800; C:lateral element; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0000150; F:DNA strand exchange activity; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:TreeGrafter.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:TreeGrafter.
DR GO; GO:0000730; P:DNA recombinase assembly; IEA:TreeGrafter.
DR GO; GO:0042148; P:DNA strand invasion; IEA:TreeGrafter.
DR GO; GO:1990918; P:double-strand break repair involved in meiotic recombination; IEA:Ensembl.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:Ensembl.
DR GO; GO:0007141; P:male meiosis I; IEA:Ensembl.
DR GO; GO:0006312; P:mitotic recombination; IEA:TreeGrafter.
DR GO; GO:0001556; P:oocyte maturation; IEA:Ensembl.
DR GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR CDD; cd19514; DMC1; 1.
DR FunFam; 3.40.50.300:FF:000239; Meiotic recombination protein DMC1; 1.
DR FunFam; 1.10.150.20:FF:000032; meiotic recombination protein DMC1/LIM15 homolog; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011940; Dmc1.
DR InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013632; Rad51_C.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR NCBIfam; NF003301; PRK04301.1; 1.
DR NCBIfam; TIGR02238; recomb_DMC1; 1.
DR PANTHER; PTHR22942:SF30; MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG; 1.
DR PANTHER; PTHR22942; RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF08423; Rad51; 1.
DR PIRSF; PIRSF005856; Rad51; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47794; Rad51 N-terminal domain-like; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003422};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR005856};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|PIRNR:PIRNR005856};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003422};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005856};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 97..270
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
FT DOMAIN 277..340
FT /note="RecA family profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50163"
SQ SEQUENCE 340 AA; 37793 MW; 8B8E3449193E4266 CRC64;
MKEDQVVAEE PRLQDEEESL FQDIDLLQKH GINVADIKKL KSVGICTIKG IQMTTRRALC
NVKGLSEAKV DKIKEAANKL IEPGFLTAFE YSEKRKMVFR ITTGSQEFDK LLGGGIESMA
ITEAFGEFRT GKTQLSHTLC VTAQLPGAGG YPGGKIIFID TENTFRPDRL RDIADRFNVD
HDAVLDNVLY ARAYTSEHQM ELLDYVAAKF HEEAGIFRLL IIDSIMALFR VDFSGRGELA
ERQQKLAQML SRLQKISEEY NVAVFVTNQM TADPGATMTF QADPKKPIGG HILAHASTTR
ISLRKGRGEL RIAKIYDSPE MPENEATFAI TAGGIGDAKE
//
