ID A0A2K6RU65_RHIRO Unreviewed; 4128 AA.
AC A0A2K6RU65;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 28-JAN-2026, entry version 39.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE AltName: Full=p460 {ECO:0000256|ARBA:ARBA00080833};
GN Name=PRKDC {ECO:0000313|Ensembl:ENSRROP00000044561.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000044561.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000044561.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSRROP00000044561.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR Ensembl; ENSRROT00000069078.1; ENSRROP00000044561.1; ENSRROG00000045235.1.
DR GeneTree; ENSGT00940000155633; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0033152; P:immunoglobulin V(D)J recombination; IEA:TreeGrafter.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:TreeGrafter.
DR GO; GO:0080135; P:regulation of cellular response to stress; IEA:UniProtKB-ARBA.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:TreeGrafter.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR FunFam; 1.10.1070.11:FF:000018; DNA-dependent protein kinase catalytic subunit; 1.
DR FunFam; 1.25.10.10:FF:000380; DNA-dependent protein kinase catalytic subunit; 1.
DR FunFam; 3.30.1010.10:FF:000013; Protein kinase, DNA-activated, catalytic subunit; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 3.30.1010.10; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR050517; DDR_Repair_Kinase.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2906..3539
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3722..4053
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4096..4128
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2065..2088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3200..3221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2065..2075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4128 AA; 469202 MW; 125A2A047553656B CRC64;
MAGSGAGVRC SLLRLQETLS AADRCGAALA GHQLIRGLGQ ECVLSSSPAV LALQTSLVFS
RDFGLLVFVR KSLNSIEFRE CREEILKFLC IFLEKMGQKI APYCVEIKNT CTSVYTKDRA
AKCKIPALDL LIKLLQTFRS SRLMDEFKIG ELFSKFYGEL ALKKKIPDTV LEKVYELLGL
LGEVHPSEMI NNAENLFRAF LGELKTQMTS AVREPKLPVL AGCLKGLSSL LCNFTKSMEE
DPQTSREIFN FVLKAIRPQI DLKRYAVPSA GLRLFALHAS QFSTCLLDNY VSLFEVLLKW
CAHTNVELKK AALSALESFL KQVSNMVAKN AEMHKSKLQY FMEQFYGIIR NVDSNNKELS
IAIRGYGLFA GPCKVINAKD VDFMYVELIQ RCKQMFLTQT DTGDDRVYQM PSFLQSVASV
LLYLDTVPEV YTPVLEHLVV MQIDSFPQYS PKMQLVCCRA IVKVFLALAA KGPVLRNCIS
TVVHQGLIRI CSKPVVLPKG PESESEDYRA SGEVRTGKWK VPTYKDYVDL FRHLLTSDQM
MDSILADEAF FSVNSSSESL NHLLYDEFIK SVLKIVEKLD LTLQTQTVGE QENGDEAPGV
WMIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKQAE FFEPWVYSFS YELILQSTRL
PLISGFYKLL SITVRNAKKI KYFEGVSPKS LKRSPEDPEK HSCFALFVKF GKEVAVKMKQ
YKDELLASCL TFLLSLPHDI IELDIRAYIP ALQMAFKLGL SYTPLAEVGL NALEEWSIYI
DRHVMQPYYK DILPCLDGYL KTSALSDETK NNWEVSALSR AAQKGFNKVV LKHLKKTKNL
SSNEAISLEE IRIRVVQMLG SLGGQINKNL LTVASSDEMM KSYVAWDREK RLSFAVPFRE
MKPVIFLDVF LPRVTELALT ASDRQTKVAA CELLHSMVMF MLGKATQMPE GGQGAPPMYQ
LYKRTFPVLL RLACDVDQVT RQLYEPLVMQ LIHWFTNNKK FESQDTVALL EAILDGIVDP
VDSTLRDFCG RCIREFLKWS IKQITPQQQE KSPVNTKSLF KRLYSLALHP NAFKRLGASL
AFNNIYREFR EEESLVEQFV FEALVIYMES LALAHADEKS LGTIQQCCDA IDHLCRIIEK
KHVSLNKAKK RRLPRGFPPS TSLCLLDLVK WLLAHCGRPQ TECRHKSIEL FYKFVPLLPG
NRSPNLWLKD VLKEEGISLI INTFEGGGCD QPSGILAQPT LLHLRGPFSL QTTLCWLDLL
LAALECYNTF IGERIVGALQ VLGTEAQSSL LKAVAFFLES IAMHDIIAAE KCFGTGAAGD
RPSPQEGERY NYSKCTIVVR IMEFTTTLLN TSPEGWKLLK KDLCNTHLMR VLVQTLCEPA
SIGFNIGDVQ VMAHLPDVCV NLMKALKMSP YKDILETHLR EKITAQRSQS GTCCPGISGP
NIIEELCAVN LYGPDAQMDR SRLAAVVSAC KQLHRAGLLH SILPSQSTDL HHSIGTELLS
LVYKGIAPGD ERQCLPSLDL SCKQLASGLL ELAFAFGGLC ERLVSLLLNP AVLSTPSLGS
LQSSVILFSH GEYFYSLFSE TINMELLKNL DLAVLELMQS SVDNPKMVST VLNGMLDQSF
RERASQKHQG LKLATTILQH WKKCDSWWAK DSPLETKMAV LALLAKILQI DSSVSFNTSH
GSFPEVFTTY ISLLADTKLD LHLKGQAVTL LPFFTSLTGG SLEELRRVLE QLIVAHFPMQ
SREFPPGTPR FNNYVDCMKK FLDALELSQS PMLLELMTEV LCREQQHVME ELFQSSFKRI
ARRGSCVTQV GLLESVYEMF RKDDPRLSFT RQSFVDRSLL TLLWHCSLDA LREFFSTIVV
DAIDVLKSRF TKLNESTFDT QITKKMGYYK ILDVMYSRLP KDDVHAKESK INQVFHGSRI
TEGNELTKTL IKLCYDAFTE NMAGENQLLE RRRLYHCAAY NCAISVICCV FNELKFYQGF
LFSEKPEKNL LIFENLIDLK RRYNFPVEVE VPMERRKKYI EIRKEAREAA NGDSDGPSYM
SSLSYLADST LSEEMSQFDF STGVQSYSYS SQDPRPTTGR FRRREQRDPT VHDDVLELEM
DELNRHECMA PLTALVKHMH RSLGPPQGEE DSVPRDLPPW MKFLHGKLGN PIVPLNIRLF
LAKLIINTEE VFRPYAKHWL SPLLQLAASE NNGGEGIHYM VVEIVATILS WTGLATPTGV
PKDEVLANRL LNFLMKHVFH PKRAVFRHNL EIIKTLVECW KDCLSIPYRL IFEKFSGKDP
NSKDNSVGIQ LLGIVMANDL PPYDPQCGIQ SSEYVFCLIY ISTFVYLKIN LIFQMLEESL
CELVAKQLKQ HQNTMEDKFI VCLNKVTKSF PPLADRFMNA VFFLLPKFHG VLKTLCLEVV
LCRVEGMTEL YFQLKSKDFV QVMRHRDDER QKVCLDIIYK MMPKLKPVEL RELLNPVVEF
VSHPSATCRE QMYNILMWIH DNYSRDPESQ TDNDSQEIFK LAKDVLIQGL IDENPGLQLI
IRNFWSHETR LPSNTLDRLL ALNSLYSPKI EVHFLSLATN FLLEMTSLSP DYPNPMFEHP
LSECEFQEYT IDSDWRFRST VLTPMFVETQ ASQGTLQTRT QEGSLSARWP MAGQIRATQQ
QHDFTPTQTA DGRSSFDWLT GSSTDPLVDH TSPSSDSLLF AHKRSERLQR APLKSVGPDF
GKKRLGLPGD EVDNKVKGAA GRVDLLRLRR RFMRDQEKLS LMYARKGVAE QKREKEIKSE
LKMKQDAQVV LYRSYRLGDL PDIQIKHSSL ITPLQAVAQR DPVIAKQLFS SLFSGILKEM
DKFKTLSEKN NITQKLLQDF NRFLNTTFSF FPPFVSCIQD ISCQHAALLS LDPAAVSAGC
LSSLQQPVGI RLLEEALLRL LPAELPAKRV RGKARLPPDV LRWVELAKLY RSIGEYDVLR
GIFSSEIGTK QITQNALLAE ARSDYSEAAK QYDEALNKQD WVDGEPTDAE KDFWELASLD
CYNHLAEWKS LEYCSTASVD SENPPDLNKI WSEPFYQETY LPYMIRSKLK LLLQGEADQS
LLTFIDKAMH GELQKAILEL HYSQELSLLY LLQDDVDRAK YYIQNGIQSF MQNYSSIDVL
LHRSRLTKLQ SVQALTEIQE FIGFISKQGN LSSQVPLKRL LNTWTNRYPD AKMDPMNIWD
DVITNRCFFL SKIEEKLTPL PEDNSMNVDE DGDPSDRMDV QEQEEDISSL IRSCKFSMKM
KMVDSARKQN NFSLAMKLLK ELHKESKTRD DWLVSWVQSY CRLSHCRSRS QGCSEQVLTV
LKTVSLLDEN NVSSYLSKNI LASRDQNILL GTTYRIIANA LSSEPACLAE IEEDKARRIL
ELSGSSSEDS EKVIAGLYQR AFQHLSEAVQ AAEEEAQPTS WSCRPAAGVI DAYMTLADFC
DQQLRKEEEN ASVTDSAELQ AYPALVVEKM LKALKLNSSE ARLKFPRLLQ IIERYPEETL
SLMTKEISSV PCWQFIGWIS HMVALLDKDQ AVAVQHTVEE ITDNYPQAIV YPFIISSESY
SFKDTSTGHK NKEFVARIKS KLDQGGVIQD FINALDQLSN PELLFKDWSN DVRAELAKTP
VNKKNIEKMY ERMYAALGDP KAPGLGAFRR KFIQTFGKEF DKHFGKGGSK LLRMKLSDFN
DITNMLLLKM NKDSKPPGNL KECSPWMSDF KVEFLRNELE IPGQYDGRGK PLPEYHVRIA
GFDERVTVMA SMRRPKRIII RGHNEREHPF LVKGGEDLRQ DQRVEQLFQV MNGILARDSA
CSQRALQLRT YSVVPMTSRL GLIEWLENTV TLKDLLLNTM SQEEKAAYLS DPKAPLCEYR
DWLTKMSGKH DVGAYLLMYK GANRTETITS FRKRESKVPA DLLKRAFVRM STSPEAFLAL
RSHFASSHAL ICISHWILGI GDRHLNNFMV AMETGGMIGI DFGHAFGSAT QFLPVPELMP
FRLTRQFINL MLPMKEMGLM YSVMVHALRA FRSDPGLLTN TMDVFVKEPS FDWKNFEQKM
LKKGGSWIQE INVAEKNWYP RQKICYAKRK LAGANPAVIT CDELLLGHEK APAFRDYVAV
ARGSKDHNIR AREPEGGLSE ETQVKCLMDQ ATDPNILGRT WEGWEPWM
//
