ID A0A2K6U581_SAIBB Unreviewed; 106 AA.
AC A0A2K6U581;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE RecName: Full=Transcription initiation factor IIA subunit 2 {ECO:0000256|ARBA:ARBA00019928, ECO:0000256|PIRNR:PIRNR009415};
GN Name=GTF2A2 {ECO:0000313|Ensembl:ENSSBOP00000027058.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000027058.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000027058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSBOP00000027058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC polymerase II and plays an important role in transcriptional
CC activation. TFIIA in a complex with TBP mediates transcriptional
CC activity. {ECO:0000256|ARBA:ARBA00024733}.
CC -!- SUBUNIT: TFIIA is a heterodimer of the large unprocessed subunit 1 and
CC a small subunit gamma. It was originally believed to be a heterotrimer
CC of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts
CC with NCOA6 general coactivator. TFIIA forms a complex with TBP.
CC Interacts with HSF1 (via transactivation domain). Part of TBP-based Pol
CC II pre-initiation complex (PIC), in which Pol II core assembles with
CC general transcription factors and other specific initiation factors
CC including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2,
CC GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large
CC multi-subunit PIC complex mediates DNA unwinding and targets Pol II
CC core to the transcription start site where the first phosphodiester
CC bond forms. {ECO:0000256|ARBA:ARBA00064462}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR009415}.
CC -!- SIMILARITY: Belongs to the TFIIA subunit 2 family.
CC {ECO:0000256|ARBA:ARBA00007675, ECO:0000256|PIRNR:PIRNR009415}.
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DR AlphaFoldDB; A0A2K6U581; -.
DR STRING; 39432.ENSSBOP00000027058; -.
DR Ensembl; ENSSBOT00000043934.1; ENSSBOP00000027058.1; ENSSBOG00000029949.1.
DR GeneTree; ENSGT00390000014572; -.
DR OMA; QYYELYR; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IEA:Ensembl.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:Ensembl.
DR GO; GO:0001091; F:RNA polymerase II general transcription initiation factor binding; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:Ensembl.
DR GO; GO:0060261; P:positive regulation of transcription initiation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:Ensembl.
DR CDD; cd10014; TFIIA_gamma_C; 1.
DR CDD; cd10145; TFIIA_gamma_N; 1.
DR FunFam; 1.10.287.190:FF:000001; Transcription initiation factor IIA subunit 2; 1.
DR FunFam; 2.30.18.10:FF:000001; Transcription initiation factor IIA subunit 2; 1.
DR Gene3D; 2.30.18.10; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR Gene3D; 1.10.287.190; Transcription factor IIA gamma subunit, alpha-helical domain; 1.
DR InterPro; IPR009083; TFIIA_a-hlx.
DR InterPro; IPR009088; TFIIA_b-brl.
DR InterPro; IPR003194; TFIIA_gsu.
DR InterPro; IPR015871; TFIIA_gsu_C.
DR InterPro; IPR015872; TFIIA_gsu_N.
DR PANTHER; PTHR10966; TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2; 1.
DR Pfam; PF02751; TFIIA_gamma_C; 1.
DR Pfam; PF02268; TFIIA_gamma_N; 1.
DR PIRSF; PIRSF009415; Hum_TFIIA_gamma; 1.
DR SUPFAM; SSF47396; Transcription factor IIA (TFIIA), alpha-helical domain; 1.
DR SUPFAM; SSF50784; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR009415};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR009415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR009415}.
FT DOMAIN 3..45
FT /note="Transcription initiation factor IIA gamma subunit N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF02268"
FT DOMAIN 56..97
FT /note="Transcription initiation factor IIA gamma subunit C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF02751"
SQ SEQUENCE 106 AA; 12112 MW; 054066839725485D CRC64;
MAYQLYRNTT LGNSLQESLD ELIQITPQLA LQVLLQFDKA INAALAQRVR NRVNFRGALN
TYRFCDNVWT FVLNDVEFRE VTELIKVEKV KIVACDGKNT GSNTTE
//
