ID A0A2K8L7N5_9PROT Unreviewed; 245 AA.
AC A0A2K8L7N5;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 28-JAN-2026, entry version 27.
DE RecName: Full=hydroxymethylpyrimidine kinase {ECO:0000256|ARBA:ARBA00012135};
DE EC=2.7.1.49 {ECO:0000256|ARBA:ARBA00012135};
GN ORFNames=Ga0123462_1396 {ECO:0000313|EMBL:ATX82259.1};
OS Mariprofundus ferrinatatus.
OC Bacteria; Pseudomonadati; Pseudomonadota; Candidatius Mariprofundia;
OC Mariprofundales; Mariprofundaceae; Mariprofundus.
OX NCBI_TaxID=1921087 {ECO:0000313|EMBL:ATX82259.1, ECO:0000313|Proteomes:UP000231637};
RN [1] {ECO:0000313|EMBL:ATX82259.1, ECO:0000313|Proteomes:UP000231637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CP-8 {ECO:0000313|EMBL:ATX82259.1,
RC ECO:0000313|Proteomes:UP000231637};
RA McAllister S.M., Kato S., Chan C.S., Chiu B.K., Field E.K.;
RT "Isolation and genomic insights into novel planktonic Zetaproteobacteria
RT from stratified waters of the Chesapeake Bay.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004948}.
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DR EMBL; CP018800; ATX82259.1; -; Genomic_DNA.
DR RefSeq; WP_100265630.1; NZ_CP018800.1.
DR AlphaFoldDB; A0A2K8L7N5; -.
DR KEGG; mfn:Ga0123462_1396; -.
DR OrthoDB; 9810880at2; -.
DR UniPathway; UPA00060; UER00138.
DR Proteomes; UP000231637; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0008902; F:hydroxymethylpyrimidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ATX82259.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000231637};
KW Transferase {ECO:0000313|EMBL:ATX82259.1}.
FT DOMAIN 16..244
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
SQ SEQUENCE 245 AA; 25451 MW; 0E1F59213DE71519 CRC64;
MSAAGRPVCL TIGGSDSCSG AGVQADLRVF EAIGVHGCSA ITALTAQNPA AITRVEPVSL
AQLDAEIHAI FDYFDVAVVK TGMLVDAEHV ALVSALLDQL HDGLLVVDPV MVSSSGRSLL
DQGGVDALQQ ALLPLATLVT PNLNEAAVLL GESITDAESA ATQLSERLGR AVLLKGGHSE
GDVLIDLLCD SDGDTRRFSH ERQPWSELQR HGTGCRLASA IAAHLAAGDL LSEAVARSVT
FLQNQ
//
