ID A0A2K8U3M3_9GAMM Unreviewed; 116 AA.
AC A0A2K8U3M3;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=Iron-sulfur cluster insertion protein ErpA {ECO:0000256|HAMAP-Rule:MF_01380};
GN Name=erpA {ECO:0000256|HAMAP-Rule:MF_01380};
GN ORFNames=THSYN_03855 {ECO:0000313|EMBL:AUB80180.1};
OS Candidatus Thiodictyon syntrophicum.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Chromatiales; Chromatiaceae; Thiodictyon.
OX NCBI_TaxID=1166950 {ECO:0000313|EMBL:AUB80180.1, ECO:0000313|Proteomes:UP000232638};
RN [1] {ECO:0000313|EMBL:AUB80180.1, ECO:0000313|Proteomes:UP000232638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cad16T {ECO:0000313|EMBL:AUB80180.1,
RC ECO:0000313|Proteomes:UP000232638};
RA Luedin S.M., Pothier J.F., Danza F., Storelli N., Wittwer M., Tonolla M.;
RT "Complete genome sequence of Candidatus 'Thiodictyon syntrophicum' sp. nov.
RT strain Cad16T, a photolithoautotroph purple sulfur bacterium isolated from
RT an alpine meromictic lake.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for insertion of 4Fe-4S clusters for at least IspG.
CC {ECO:0000256|HAMAP-Rule:MF_01380}.
CC -!- COFACTOR:
CC Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01380};
CC Note=Binds 1 iron-sulfur cluster per subunit. {ECO:0000256|HAMAP-
CC Rule:MF_01380};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01380}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family. {ECO:0000256|HAMAP-
CC Rule:MF_01380}.
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DR EMBL; CP020370; AUB80180.1; -; Genomic_DNA.
DR RefSeq; WP_100917985.1; NZ_CP020370.1.
DR AlphaFoldDB; A0A2K8U3M3; -.
DR KEGG; tsy:THSYN_03855; -.
DR OrthoDB; 9801228at2; -.
DR Proteomes; UP000232638; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR FunFam; 2.60.300.12:FF:000002; Iron-sulfur cluster insertion protein ErpA; 1.
DR Gene3D; 2.60.300.12; HesB-like domain; 1.
DR HAMAP; MF_01380; Fe_S_insert_ErpA; 1.
DR InterPro; IPR016092; ATAP.
DR InterPro; IPR000361; ATAP_core_dom.
DR InterPro; IPR023063; ErpA_proteobact.
DR InterPro; IPR017870; FeS_cluster_insertion_CS.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR NCBIfam; TIGR00049; iron-sulfur cluster assembly accessory protein; 1.
DR NCBIfam; NF010147; PRK13623.1; 1.
DR PANTHER; PTHR43011; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43011:SF1; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; HesB-like domain; 1.
DR PROSITE; PS01152; HESB; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|HAMAP-Rule:MF_01380};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|HAMAP-
KW Rule:MF_01380};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_01380}; Reference proteome {ECO:0000313|Proteomes:UP000232638}.
FT DOMAIN 11..111
FT /note="Core"
FT /evidence="ECO:0000259|Pfam:PF01521"
FT BINDING 44
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01380"
FT BINDING 108
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01380"
FT BINDING 110
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01380"
SQ SEQUENCE 116 AA; 12286 MW; 62DB6EC9A1371041 CRC64;
MSTENPTDLP LIFTASAAAK VAQLIVEEGK PELMLRVYVQ GGGCSGFQYG FTFDESVQDG
DTEVVTDGVK LLIDPMSMQY LTGAEIDYTE GLQGAQFVIR NPSASTTCGC GSSFAV
//
