ID A0A2N9JDA2_9ACTN Unreviewed; 601 AA.
AC A0A2N9JDA2;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=MPLG2_0504 {ECO:0000313|EMBL:SPD85540.1};
OS Micropruina glycogenica.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Micropruina.
OX NCBI_TaxID=75385 {ECO:0000313|EMBL:SPD85540.1, ECO:0000313|Proteomes:UP000238164};
RN [1] {ECO:0000313|EMBL:SPD85540.1, ECO:0000313|Proteomes:UP000238164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1 {ECO:0000313|EMBL:SPD85540.1};
RA Cohen D.B., Kent A.D.;
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; LT985188; SPD85540.1; -; Genomic_DNA.
DR RefSeq; WP_105184748.1; NZ_BAAAGO010000042.1.
DR AlphaFoldDB; A0A2N9JDA2; -.
DR KEGG; mgg:MPLG2_0504; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000238164; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SPD85540.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000238164}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 601 AA; 64635 MW; C1A274D7D72A36EB CRC64;
MYVVATAGHV DHGKSTLVRA LTGMEPDRLA EEQRRGLTID LGFAWTTLPS GREVAFVDVP
GHERFLGNML AGVGPAPAVC FVVAADQGWQ AQSSDHLDAV VALGITAGLV VITRADLATA
DQLAATKTEI ESRLGRTPLS NAPVLAVSAV NRTGWEHLLN TLDQVLAQVP EPDPEARVRL
WIDRSFSIRG AGTVVTGTLT AGTLRRHDRL DLVGVDGRRP VRVRGLQSRN ESVPLVTPHA
RAAVNLREVP AEAVHRGDAL VSPDAWPIVI QFDVRRTTGA GFDDLPQQLM VHVGTAAVPA
RVRPFDHEHA RLTLDRALPL KVDDRLVLRT PGGHVVLAGV LVLDVDPPEL RRRGDGARLA
VDLANRPVGG DPATEVARRG AMRPEQLWRF GLARLTAPPE GVAEKDGWWV DRAVLGAWAA
SLTRAVDRVH ESEPLSPGLS DGAALDLLRH EDPPLPEAAL LALVVSAAGL ESVRGAVRRP
GRPNDLGAAE AAIVQLEQRL REQPFAAPEA EELTALRLGP RELAAAERAG RLLRLDGAVV
LLPQAPALAM RTLAGLTQPF TTSEARRAMN TTRRVAIPLL ELLDARGWTR RLDGTLRTVV
R
//
