ID A0A2R9BNC9_PANPA Unreviewed; 648 AA.
AC A0A2R9BNC9;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE RecName: Full=Sodium/nucleoside cotransporter {ECO:0000256|RuleBase:RU362018};
GN Name=SLC28A1 {ECO:0000313|Ensembl:ENSPPAP00000031156.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000031156.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000031156.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000031156.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC ECO:0000256|RuleBase:RU362018}.
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DR EMBL; AJFE02021805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02021806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02021807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02021808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02021809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02021810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02021811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02021812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02021813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008957825.1; XM_008959577.1.
DR AlphaFoldDB; A0A2R9BNC9; -.
DR STRING; 9597.ENSPPAP00000031156; -.
DR Ensembl; ENSPPAT00000054020.1; ENSPPAP00000031156.1; ENSPPAG00000038512.1.
DR GeneTree; ENSGT00390000016025; -.
DR OMA; IVWHTVI; -.
DR Proteomes; UP000240080; Chromosome 15.
DR Bgee; ENSPPAG00000038512; Expressed in adult mammalian kidney and 2 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:1901474; F:azole transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015389; F:pyrimidine- and adenosine-specific:sodium symporter activity; IEA:Ensembl.
DR GO; GO:0015213; F:uridine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015861; P:cytidine transport; IEA:Ensembl.
DR GO; GO:0180015; P:nucleoside import across plasma membrane; IEA:Ensembl.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR NCBIfam; TIGR00804; nupC; 1.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF16; SODIUM_NUCLEOSIDE COTRANSPORTER 1; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362018};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT TRANSMEM 81..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 110..128
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 148..167
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 179..195
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 262..281
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 338..360
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 367..386
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 424..446
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 458..479
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 532..556
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 568..592
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT DOMAIN 183..255
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 263..361
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 367..588
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
SQ SEQUENCE 648 AA; 71364 MW; C8E63341B8B136D0 CRC64;
MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS WSEAAPKPFS
RWRNLQPALR ARSFCREHMQ LFRWIGTGLL CTGLAAFLLV ACLLDFQRAL ALFVLTCVVL
TFLGHRLLKR LLGPKLRRFL KPQGHPRLLL WFKRGLALAA FLGLVLWLSL DTSQRPEQLV
SFAGICVFIA LLFACSKHHC AVSWRAVSWG LGLQFVLGLL VIRTEPGFIA FEWLGEQIRI
FLSYTKAGSS FVFGEALVKD VFAFQVLPII VFFSCVISIL YHVGLMQWVI LKIAWLMQVT
MGTTATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA GSLLGAYISF
GIDATSLIAA SVMAAPCALA LSKLVYPEVE ESKFRREEGV KLTYGDAQNL IEAASTGAAI
SVKVVANIAA NLIAFLAVLD FINAALSWLG DMVDVQGLSF QLICSYILRP VAFLMGVAWE
DCPVVAELLG IKLFLNEFVA YQDLSKYKQR RLAGAEEWVG DRKQWISVRA EVLTTFALCG
FANFSSIGIM LGGLTSMVPQ RKSDFSQIVL RALFTGACVS LVNACMAGIL YVPRGAGVDC
MSLLNTTLSS SSFEIYQCCR EAFQSINPEF SPEALDNCCR FYNHTICA
//
