ID A0A2R9BXM9_PANPA Unreviewed; 512 AA.
AC A0A2R9BXM9;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 28-JAN-2026, entry version 39.
DE SubName: Full=Forkhead box N4 {ECO:0000313|Ensembl:ENSPPAP00000031267.1};
GN Name=FOXN4 {ECO:0000313|Ensembl:ENSPPAP00000031267.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000031267.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000031267.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000031267.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSPPAP00000031267.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; AJFE02116861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02116862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02116863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02116864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BXM9; -.
DR STRING; 9597.ENSPPAP00000031267; -.
DR Ensembl; ENSPPAT00000054131.1; ENSPPAP00000031267.1; ENSPPAG00000038569.1.
DR GeneTree; ENSGT00940000158984; -.
DR OMA; QCPTSVY; -.
DR Proteomes; UP000240080; Chromosome 12.
DR Bgee; ENSPPAG00000038569; Expressed in testis.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0035881; P:amacrine cell differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0010842; P:retina layer formation; IEA:Ensembl.
DR GO; GO:0060579; P:ventral spinal cord interneuron fate commitment; IEA:Ensembl.
DR CDD; cd20057; FH_FOXN4; 1.
DR FunFam; 1.10.10.10:FF:000122; Forkhead box protein N1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR047119; FOXN2/3-like.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13962; FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR13962:SF17; FORKHEAD BOX PROTEIN N4; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 188..284
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 188..284
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 115..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 54657 MW; 6726571E7233B970 CRC64;
MIESDTSSIM SGIIRNSGQN HHPSPQEYRL LATTSDDDLP GDLQSLSWLT AVDVPRLQQM
ASGRVDLGGP CVPHPHPGAL AGVADLHVGA TPSPLLHGPA GMAPRGMPGL GPITGHRDSV
SVPHGGQPSS GLQDPPHLYS PATQPQFPLP PVPSCGPLWL PIWGAAPYPQ PHVAVHSSQE
LHPKHYPKPI YSYSCLIAMA LKNSKTGSLP VSEIYSFMKE HFPYFKTAPD GWKNSVRHNL
SLNKCFEKVE NKMSGSSRKG CLWALNLARI DKMEEEMHKW KRKDLAAIHR SMANPEELDK
LISDRPESCR RPGKPGEPEA PVLTHATTVA VAHGCLAVSQ LPPQPLMTLS LQSVPLHHQV
QPQAHLAPDS PAPAQTPPLH ALPDLSPSPL PHPAMGRAPV DFINISTDMN TEVDALDPSI
MDFALQGNLW EEMKDEGFSL DTLGAFGDSP LGCDLGASGL TPASGGSDQS FPDLQVTGLY
TAYSTPDSVA ASGTSSSSQY LGAQGNKPIA LL
//
