ID A0A2S4L5H6_9HYPO Unreviewed; 323 AA.
AC A0A2S4L5H6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 08-OCT-2025, entry version 15.
DE SubName: Full=L-threo-3-deoxy-hexylosonate aldolase {ECO:0000313|EMBL:POR37667.1};
GN ORFNames=TPAR_02133 {ECO:0000313|EMBL:POR37667.1};
OS Tolypocladium paradoxum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Tolypocladium.
OX NCBI_TaxID=94208 {ECO:0000313|EMBL:POR37667.1, ECO:0000313|Proteomes:UP000237481};
RN [1] {ECO:0000313|EMBL:POR37667.1, ECO:0000313|Proteomes:UP000237481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRBC 100945 {ECO:0000313|EMBL:POR37667.1,
RC ECO:0000313|Proteomes:UP000237481};
RA Quandt C.A., Patterson W., Spatafora J.W.;
RT "Harnessing the power of phylogenomics to disentangle the directionality
RT and signatures of interkingdom host jumping in the parasitic fungal genus
RT Tolypocladium.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POR37667.1}.
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DR EMBL; PKSG01000219; POR37667.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S4L5H6; -.
DR STRING; 94208.A0A2S4L5H6; -.
DR OrthoDB; 191315at2759; -.
DR Proteomes; UP000237481; Unassembled WGS sequence.
DR GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IEA:TreeGrafter.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF66; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000237481}.
FT ACT_SITE 153
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 183
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 227
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 323 AA; 34712 MW; EE4BD6124466E78F CRC64;
MSGHQPSSTM ATPCPPRGIY VPAVAFFNED ETLDFDAIKV HLTRMAKAGV DGLVIQGSNG
EAMHLDHAER QEVLRLARTV LQEHGKPGAV IVAGGGAQST RESIRLCKEA KEAGADYALV
LSPSYWVGAM QKPTIYKFFD DVATASPMPI LLYNFPGVTS GIDLDSDMII NLAAANPKVV
GCKLTCGNMG KLQRVAHDAR IGRPFAAFAG KTDFLLHGLV GGSHGVIAAA ANMFPKAHVH
MLRLYDEGRL KEAQGLQTRF SRADWALVQL GVAGLKAALD KYYGYGAGRS RRPLGFVEGT
KFEGDTDAVL RNLVDFENSL PDI
//
