ID A0A2T0AS61_9FIRM Unreviewed; 634 AA.
AC A0A2T0AS61;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 28-JAN-2026, entry version 31.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:PRR72906.1};
GN ORFNames=MOHU_13290 {ECO:0000313|EMBL:PRR72906.1};
OS Neomoorella humiferrea.
OC Bacteria; Bacillati; Bacillota; Clostridia; Neomoorellales;
OC Neomoorellaceae; Neomoorella.
OX NCBI_TaxID=676965 {ECO:0000313|EMBL:PRR72906.1, ECO:0000313|Proteomes:UP000238415};
RN [1] {ECO:0000313|EMBL:PRR72906.1, ECO:0000313|Proteomes:UP000238415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23265 {ECO:0000313|EMBL:PRR72906.1,
RC ECO:0000313|Proteomes:UP000238415};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Moorella humiferrea DSM 23265.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRR72906.1}.
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DR EMBL; PVXM01000025; PRR72906.1; -; Genomic_DNA.
DR RefSeq; WP_106005304.1; NZ_CP136419.1.
DR AlphaFoldDB; A0A2T0AS61; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000238415; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015189; Elong_fac_SelB-wing-hlx_typ-1.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09105; WHD_1st_SelB; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 4.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:PRR72906.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000238415}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 634 AA; 70307 MW; 338031AFB5B93CD7 CRC64;
MEYIIVGTAG HVDHGKTVLV KALTGVDTDR LKEEKERGIS IELGFAPLRL PSGRLLGLVD
VPGHERFIRQ MLAGVGGMDL VMLVVAADEG VMPQTREHLA IIDLLQIKKG IIVITKIDLV
DGEWLDLVQE DVRRSVQGTV LADAPIIPVS AVTGEGIPEL LNKLDELAAV TPPRPARGGV
RLPIDRVFSI TGFGTVVTGT LWTGTIKVGD DLEILPQGIK TKARNLQVHG KNVREALAGQ
RVAVNLAGVD KEAVGRGSTL ATPGHLPSAR RIDATVKLLS GSRTIENRSR IRFYLGTAEI
LGRIILLDRE EIKGGENALV QFLMEEPVVS LRGDRFVLRS YSPMETIGGG VVIDPDAPRH
RRFDTNVLAS LRKKLEGTPG EVLAQIIKEH RQGINLTEAA AAAAMNVDDA RELLHGMAAE
GLFVMLPCEH DLYIVDREIM DAWWRETERA LTDFHCRYPL RPGLGKEELR SRCFSQIPAR
VFQPLLEQWS REGRIVFTAG TVALAGFKPD LTPKQKELLE GIAAYYRTAR WQPPDFKGVA
ANFKVQPSEL EELLHYLVRE GVLVKINEEF YWHREAFEEA VNVVRELGRT GPFGLAEVRD
ALGSSRKFIL PFLEYLDRLK LTRRQGDKRI FIAN
//
