ID A0A2T1HQU9_9HYPH Unreviewed; 647 AA.
AC A0A2T1HQU9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:PSC04023.1};
GN ORFNames=SLNSH_15545 {ECO:0000313|EMBL:PSC04023.1};
OS Alsobacter soli.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Hyphomicrobiales; Alsobacteraceae; Alsobacter.
OX NCBI_TaxID=2109933 {ECO:0000313|EMBL:PSC04023.1, ECO:0000313|Proteomes:UP000239772};
RN [1] {ECO:0000313|Proteomes:UP000239772}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH9 {ECO:0000313|Proteomes:UP000239772};
RA Sun L., Liu H., Chen W., Huang K., Liu W., Gao X.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSC04023.1}.
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DR EMBL; PVZS01000017; PSC04023.1; -; Genomic_DNA.
DR RefSeq; WP_106337930.1; NZ_PVZS01000017.1.
DR AlphaFoldDB; A0A2T1HQU9; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000239772; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF9; GTP-BINDING PROTEIN 1; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:PSC04023.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000239772}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 647 AA; 69256 MW; 687D1F8C9BB172BF CRC64;
MIVGTAGHID HGKSSLVRSI TGVDPDRLKE EKARGITIDL GFAYWPQPDG SVIGFVDVPG
HERFVHTMLA GAAGVDLALL VVAADDGVMP QTREHLAILD LLGLTRGVVA LTKADLVEPA
RLAAVKAEIA ETLAGTGLAG SPILPVSSAT GAGVRDLERC LAEESKKTAA RRDAGLFRLT
VDRCFTLAGA GAVVTGTVVA GSVGVGDSVM VSPSGIEARV RSIRAQNRPA ERGRAGDRCA
LNIAGPGVAK DAVRRGDVVL DPRLHAPTLR LDAELLVLPS EPKGVGLWMP VWLHIGGAEV
AARIVPLQDG VIRPGTGGRV QLVLEKPVAA TDLERFVIRD TSATRTIGGG RVLDLRAPER
KRRTPERLAQ LDALSLGLPE DALAALARVP PNHVSARAFA RDHGVAIENI LSMAETRSLV
RLPVGEDVAL LDPAFWLSLK RGVLASLAAW HEANPDLAGI GAERLRLQLD RRLPAPVFRA
ALQALARPAS GAAGIALDGA WVRLASHVVR LSQDDEALWG RMRPLIAGQE RFRPPRVRDI
AGLLDVEEAR VRRAFRLVGR RGEVDEVAHD HFFLRPTVAE MVGVAADLAA HGPKGEFTAA
QFRDRLDNGR KVAIQILEFF DRYGVTMRRG DLRRINRHRL DLFGTSA
//
