ID A0A2U1MTN7_ARTAN Unreviewed; 1351 AA.
AC A0A2U1MTN7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE SubName: Full=Disease resistance protein {ECO:0000313|EMBL:PWA64612.1};
GN ORFNames=CTI12_AA340620 {ECO:0000313|EMBL:PWA64612.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA64612.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA64612.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA64612.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA64612.1}.
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DR EMBL; PKPP01004392; PWA64612.1; -; Genomic_DNA.
DR STRING; 35608.A0A2U1MTN7; -.
DR OrthoDB; 25838at2759; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProtKB-ARBA.
DR FunFam; 3.40.50.300:FF:001091; Probable disease resistance protein At1g61300; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR056789; LRR_R13L1-DRL21.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR058922; WHD_DRP.
DR PANTHER; PTHR36766:SF61; NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF25019; LRR_R13L1-DRL21; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR Pfam; PF23559; WHD_DRP; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1351
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015545996"
FT DOMAIN 11..97
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 183..322
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 412..480
FT /note="Disease resistance protein winged helix"
FT /evidence="ECO:0000259|Pfam:PF23559"
FT DOMAIN 676..802
FT /note="R13L1/DRL21-like LRR repeat region"
FT /evidence="ECO:0000259|Pfam:PF25019"
SQ SEQUENCE 1351 AA; 152647 MW; B64DC0C435D0EA69 CRC64;
MAVAEIFLGA FITVLFEKLA SADLIRLARA AGIYSELDKW NNTLSQIQAV LVDAGQKHIR
DNSVQLWLYK LQHLAYEIDD VLDDLATEAM RHQSNEESDA SSCTGTSKVL TMIPSCCTSF
TPRTIMYGGK MSFKLDEITT KLHSLVEEKN LLGLINNVER SNKTTRRLEE TSLVDLSIIV
GREGDKKALL EKLLSNEPCN KNFSILSIVG LGGIGKTTLA QVLYNDTKVK DHFKLMSWVC
VSDEFDVFSI SKAIYKDVGG EHKKFETLNQ LQVALTEKLS NKKFILVLDD VWNENYNEWE
LLQRPFAVGA PGSKIVVTTR KTMHALGKQN FESHPTLQSY GEEIVKKCGG LPLALRTLGR
VLRTKSTEEE WEELLNSELW HVQNGDKILP ALRLSYYDLP PHLKQMFAYC CLFPKDYVFD
KDEIVLLWMA EGFLYDSNGS KLMESLGREC FEELESRSFF QKSTNDKSRY IMHELINDLA
TSVAKEFFFM LGDKMDVYDM NEVLDKLHHM SFIRERYGVY RKFKALQRAR RLRTFLAMSV
TRLFTWQRFY LSEKVLTELL PQLRFLRVLS LANYNIREVP QSIGSLKHMR YLNFSNTDIK
CLPEVVGDLY NLQSLLVSGC PHLSSLPNSI IKLISLRHLD ISNTPKLNKM SSGFGGLTGL
QTLSKVVIGG ADEFKISDLK SLVHLQGQLS IEGLHKVINA VHAKEANLLQ KKGLRDLEMK
WSDVFDSSRN ESTEYEVLEG LRPFEKLTSL KILYYMGTKF PSWVGDPSFV CLNQLTLRGC
RSKCLPTLGH LPLLQKLFVQ NMNGLQRLGV ELLGDPNSSH GVAFPSLEVL EFKDMQGWEE
WSASGDEKDG VVRSFPRLRE LYVLDCPMLD VVAIGLIPSL RVLHIQGCSV AVLRSMVGVS
SSIIRLVMSN IKGLTQLHGK VLEDLWAVEY LQISQCDELT HLWKTEVEAC EILVSLQKLE
VSGLVMSNIK GLTQLHGKVL EDLWAVEYLQ ISQCDELTHL WKTEVEACEI LVSLQKLEVS
GCVNLVSLGE KEMDLVISME SCREVEINSC PRLESYYCPN SIEKLKISGC GSVTSLTFPT
QNSLPSNLKI LNIEDCDNLE VSWLLNNFLS SLESLVLYKI PKLRSFPAGC LVHLTTLIIS
SCDNIEYIPG DGLGFRPFLC LKSLLINNCK NLKSFPHEHL QSLASLEYMW ISYCPNLDYS
FPCGLWPPKL SNLSIGGLKK PISEWGLQNF PPSLVTLILY GENSGVVPFS KAEDMMNSSS
TTTSPFLIPS TLTYLYISDL LDLESLSKDL KHLTSLEELV IFSCPKVRDL PVTLLPSLSR
LWVKNCPKLG NKCKKGDYWP IISQIPDLDV E
//
