ID A0A2U1PY37_ARTAN Unreviewed; 772 AA.
AC A0A2U1PY37;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN ORFNames=CTI12_AA041470 {ECO:0000313|EMBL:PWA90689.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA90689.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA90689.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA90689.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000032,
CC ECO:0000256|RuleBase:RU361203};
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|ARBA:ARBA00008723,
CC ECO:0000256|RuleBase:RU361203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA90689.1}.
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DR EMBL; PKPP01000608; PWA90689.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1PY37; -.
DR STRING; 35608.A0A2U1PY37; -.
DR OrthoDB; 45007at2759; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00839; MPP_PAPs; 2.
DR FunFam; 2.60.40.380:FF:000001; Fe(3+)-Zn(2+) purple acid phosphatase; 1.
DR FunFam; 3.60.21.10:FF:000034; Fe(3+)-Zn(2+) purple acid phosphatase; 2.
DR Gene3D; 3.60.21.10; -; 2.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR039331; PAPs-like.
DR InterPro; IPR025733; PAPs_C.
DR InterPro; IPR015914; PAPs_N.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR PANTHER; PTHR22953; ACID PHOSPHATASE RELATED; 1.
DR PANTHER; PTHR22953:SF55; BIFUNCTIONAL PURPLE ACID PHOSPHATASE 26; 1.
DR Pfam; PF00149; Metallophos; 2.
DR Pfam; PF14008; Metallophos_C; 2.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 2.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361203};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 61..153
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 164..361
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 387..445
FT /note="Purple acid phosphatase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14008"
FT DOMAIN 479..668
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 694..752
FT /note="Purple acid phosphatase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14008"
SQ SEQUENCE 772 AA; 89246 MW; 19149C9E890F38B2 CRC64;
MNIPKDKKMI PKFLVLGYIL LSFVGNVYAG VTSSFVRQVF PAEDMPLDHP VFAKPSGYNA
PEQVHITQGD YDGKAVIIMW VTPDEPGSNE VRYGTSKNKY NFVAQGMKVK KYKFYNYTSG
YNHKCLVDGL EYDTKYYYEI GDGDSARSFW FKTPPKVDPN AYHKFGLIGD LGQTYNSLST
FEHYMQSGAK TVLFVGDLSY SDEHEYYDVG LRWDTYGRFV EKSTAYQQWL WTVGNHEIEY
LPEYDEVETF KQYLHRYETP YAASESTSPL WYAVRVASAH IIFLSSYSPF VKYTPQYEWL
KAEFKKVDRE KTPWLIVIMH SPMYNSNSAH YMEGESMRVV YESWFVENKV DIVLAGHVHA
YERSYRISNI HYNITGGVSY PVPDKSAPIY INIGDGGNLE GLASTYNDPQ PHYSAFREAS
YGYATLEIMN KTHAIYHWNR NDVGKSVQAD SLVLHNQYCN HLDNDAISRT TNTQLCDLGQ
TYNSLSTFEH YMQSGAKTVL FVGDLSYSDE HQYYDVGLRW DTYGRFVEKS TAYQQWLWTV
GNHEIEYLPE YDEVETFKQY LHRYETPYAA SGSTSPLWYA VRVASAHIIF LSSYSPFVKY
TPQYEWLKAE FKKVDREKTP WLIVIMHSPM YNSNSAHYME GESMRVAYES WFVENKVDIV
LAGHVHAYER SYRISNIHYN ITGGVSYPVP DKSAPIYINI GDGGNLEGLA STYNDPQPHY
SAFREASYGY ATLEIMNKTH AIYHWNRNDV GKSVQADSLV LHNQYWSLKD TK
//
