ID A0A2V3KKH8_KLEVA Unreviewed; 613 AA.
AC A0A2V3KKH8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:QNP24959.1};
GN ORFNames=AN2335V1_3718 {ECO:0000313|EMBL:CAH6166186.1}, IAP99_00870
GN {ECO:0000313|EMBL:QNP24959.1};
OS Klebsiella variicola.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
OC Klebsiella; Klebsiella pneumoniae complex.
OX NCBI_TaxID=244366 {ECO:0000313|EMBL:QNP24959.1, ECO:0000313|Proteomes:UP000516181};
RN [1] {ECO:0000313|EMBL:QNP24959.1, ECO:0000313|Proteomes:UP000516181}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KP2757 {ECO:0000313|EMBL:QNP24959.1,
RC ECO:0000313|Proteomes:UP000516181};
RA Zhang X.;
RT "Complete genome sequence of Klebsiella pneumoniae KP2757.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAH6166186.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=0 {ECO:0000313|EMBL:CAH6166186.1};
RA Alioto T., Alioto T., Gomez Garrido J.;
RL Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAJOXS020000003; CAH6166186.1; -; Genomic_DNA.
DR EMBL; CP060807; QNP24959.1; -; Genomic_DNA.
DR RefSeq; WP_044643356.1; NZ_BQTQ01000002.1.
DR AlphaFoldDB; A0A2V3KKH8; -.
DR Proteomes; UP000516181; Chromosome.
DR Proteomes; UP000789617; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IEA:TreeGrafter.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:TreeGrafter.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR GO; GO:0016259; P:selenocysteine metabolic process; IEA:TreeGrafter.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 1.10.10.10:FF:000350; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 2.40.30.10:FF:000080; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR050543; eIF2G.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048649; WHD_1st_3rd_SelB.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF21458; WHD_1st_3rd_SelB; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:QNP24959.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000789617}.
FT DOMAIN 1..169
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 613 AA; 68581 MW; CC64D7FA16094D21 CRC64;
MIIATAGHVD HGKTTLLQAI TGVNADRLPE EKARGMTIDL GYAYWPQPDG RVLGFIDVPG
HEKFLSNMLA GVGGIDHALL VVACDDGVMA QTREHLAILQ LTGKPTLTVA LTKTDRVAAA
RVEEVRAEVE QTLRELGFDA VAFFPTAAAE NIGIAELRSH LLQLAERPHP QQQRFRLALD
RAFTVKGAGL VVTGTALSGE VRVGDTLWLT GVNTPMRVRG LHAQNQAVEQ AHAGQRIALN
IVGDAQKEAV HRGDWLLSSP PPEPAERVIV ELQCHTPLSQ WQPLHIHHAA SHITGRVSLL
EGNLAELVLD TPLWLADNDR LVLRDISARL TLAGARVVTL DPPRRGKRKP EYLQWLHALA
AVGADDAPAL ELHLQRDAVR LERFAWARQL SEAGMAALIQ RPDYLQAGQR LLSAPLAARW
QRKLLDALAR YHEQHRDEPG PGRERLRRIA LPMEDEALVL LLIEQMRESG LVHSHHGWLH
LPEHKAGFTD EQQAVWQKVE ALFGDDPWWV RDLAREVHVE ESLMRAVLRQ AAQQGMITAI
VKDRYYRNDR IVQFAQRVRE LDQLRGSTCA ADFRDTLNVG RKLAIQILEY FDRIGFTRRR
GNDHILRDKA LFL
//
