ID A0A2W1BUL7_HELAM Unreviewed; 207 AA.
AC A0A2W1BUL7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 02-APR-2025, entry version 26.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=HaOG217230 {ECO:0000313|EMBL:PZC78772.1};
GN ORFNames=B5X24_HaOG217230 {ECO:0000313|EMBL:PZC78772.1};
OS Helicoverpa armigera (Cotton bollworm) (Heliothis armigera).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Helicoverpa.
OX NCBI_TaxID=29058 {ECO:0000313|EMBL:PZC78772.1, ECO:0000313|Proteomes:UP000249218};
RN [1] {ECO:0000313|EMBL:PZC78772.1, ECO:0000313|Proteomes:UP000249218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Harm_GR_Male_#8 {ECO:0000313|EMBL:PZC78772.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PZC78772.1};
RX PubMed=28756777; DOI=10.1186/s12915-017-0402-6;
RA Pearce S.L., Clarke D.F., East P.D., Elfekih S., Gordon K.H., Jermiin L.S.,
RA McGaughran A., Oakeshott J.G., Papanikolaou A., Perera O.P., Rane R.V.,
RA Richards S., Tay W.T., Walsh T.K., Anderson A., Anderson C.J., Asgari S.,
RA Board P.G., Bretschneider A., Campbell P.M., Chertemps T.,
RA Christeller J.T., Coppin C.W., Downes S.J., Duan G., Farnsworth C.A.,
RA Good R.T., Han L.B., Han Y.C., Hatje K., Horne I., Huang Y.P., Hughes D.S.,
RA Jacquin-Joly E., James W., Jhangiani S., Kollmar M., Kuwar S.S., Li S.,
RA Liu N.Y., Maibeche M.T., Miller J.R., Montagne N., Perry T., Qu J.,
RA Song S.V., Sutton G.G., Vogel H., Walenz B.P., Xu W., Zhang H.J., Zou Z.,
RA Batterham P., Edwards O.R., Feyereisen R., Gibbs R.A., Heckel D.G.,
RA McGrath A., Robin C., Scherer S.E., Worley K.C., Wu Y.D.;
RT "Genomic innovations, transcriptional plasticity and gene loss underlying
RT the evolution and divergence of two highly polyphagous and invasive
RT Helicoverpa pest species.";
RL BMC Biol. 15:63-63(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR EMBL; KZ149896; PZC78772.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W1BUL7; -.
DR EnsemblMetazoa; XM_049851953.1; XP_049707910.1; LOC110375521.
DR OrthoDB; 10009520at2759; -.
DR Proteomes; UP000249218; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20352; Rcat_RBR_RNF144; 1.
DR FunFam; 1.20.120.1750:FF:000010; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000249218};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT TRANSMEM 139..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..125
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT REGION 187..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 207 AA; 22669 MW; C27B65C6854D3E99 CRC64;
MDSGRAFCPR VGCDTVVHVR AASPAHCPTC RHDFCSQCNQ EWHGGLSCEA AAASSSMGGA
GAPLLPDSEL IKLCPMCRVP IEKDEGCAQM MCKRCKHVFC WYCLASLDDD FLLRHYDKGP
CKNKLGHSRA SVLWHRAQVV GIFAGFGLLL LVASPLLLLA APCIVCCKCR LCNPNHKNLE
EVDEIDSISP TRDDDGDDTR PTRYLSD
//
