ID A0A2W1CTD0_9PLEO Unreviewed; 315 AA.
AC A0A2W1CTD0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 05-FEB-2025, entry version 21.
DE SubName: Full=DapA, Dihydrodipicolinate synthase-N-acetylneuraminate lyase {ECO:0000313|EMBL:KAF7565519.1};
DE SubName: Full=Dihydrodipicolinate synthetase protein {ECO:0000313|EMBL:KAI1512576.1};
GN ORFNames=Ptr86124_008542 {ECO:0000313|EMBL:KAI1512576.1}, PtrM4_049530
GN {ECO:0000313|EMBL:KAF7565519.1};
OS Pyrenophora tritici-repentis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=45151 {ECO:0000313|EMBL:KAI1512576.1, ECO:0000313|Proteomes:UP000249757};
RN [1] {ECO:0000313|EMBL:KAF7565519.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M4 {ECO:0000313|EMBL:KAF7565519.1};
RX PubMed=29685100; DOI=10.1186/s12864-018-4680-3;
RA Moolhuijzen P., See P.T., Hane J.K., Shi G., Liu Z., Oliver R.P.,
RA Moffat C.S.;
RT "Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-
RT repentis reveals chromosomal variations and genome plasticity.";
RL BMC Genomics 19:279-279(2018).
RN [2] {ECO:0000313|EMBL:KAI1512576.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=86-124 {ECO:0000313|EMBL:KAI1512576.1};
RA Moolhuijzen P.M., Moffat C.S.;
RL Submitted (MAY-2021) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAI1512576.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=86-124 {ECO:0000313|EMBL:KAI1512576.1};
RA Moolhuijzen P., See P.T., Shi G., Powell H.R., Cockram J., Jorgensen L.N.,
RA Benslimane H., Strelkov S.E., Turner J., Liu Z., Moffat C.S.;
RT "A global pangenome for the wheat fungal pathogen Pyrenophora tritici-
RT repentis and prediction of effector protein structural homology.";
RL bioRxiv 0:0-0(2022).
RN [4] {ECO:0000313|Proteomes:UP000249757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=36214662;
RA Moolhuijzen P.M., See P.T., Shi G., Powell H.R., Cockram J.,
RA Jorgensen L.N., Benslimane H., Strelkov S.E., Turner J., Liu Z.,
RA Moffat C.S.;
RT "A global pangenome for the wheat fungal pathogen Pyrenophora tritici-
RT repentis and prediction of effector protein structural homology.";
RL Microb. Genom. 8:0-0(2022).
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAI1512576.1}.
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DR EMBL; NQIK02000010; KAF7565519.1; -; Genomic_DNA.
DR EMBL; NRDI02000011; KAI1512576.1; -; Genomic_DNA.
DR OMA; KHAVACY; -.
DR OrthoDB; 191315at2759; -.
DR Proteomes; UP000245464; Chromosome 10.
DR Proteomes; UP000249757; Unassembled WGS sequence.
DR GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IEA:TreeGrafter.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR PANTHER; PTHR12128:SF47; DIHYDRODIPICOLINATE SYNTHASE-RELATED; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|PIRNR:PIRNR001365, ECO:0000313|EMBL:KAF7565519.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000249757}.
FT ACT_SITE 142
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 173
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 216
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 315 AA; 33120 MW; 13748D95458B652E CRC64;
MAPPPSAGVW CPAVTFYTPE SDTATLDLVA QKQYFTYLSK SGLIGLVVLG SNAEAFLLTR
DEKKALMKCA REAVGPDYPL MVGISGFSVP QVMENISDAI EAGANYGLLL PAAYYGPATS
KDVIMAFYNE VAQKSSLPIV IYNFPGTCNG VDLDSVTIAA LAKRNPGKIV GVKLTCGSVA
KITRLCAELP SDTFSTFAGQ ADWMVAGLAV GSAGCVSAFS NVFPKVCSKV YELYTSGKTQ
EALELHRKAA LAESPIKAGI APTKHAVSQY SAKAAGIEGA EAKLNPRRPY SPVAEALKAS
VKDTMAELAT IENSL
//
