ID A0A2W2CD74_9ACTN Unreviewed; 587 AA.
AC A0A2W2CD74;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:PZF89798.1};
GN ORFNames=C1I99_25080 {ECO:0000313|EMBL:PZF89798.1};
OS Micromonospora deserti.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=2070366 {ECO:0000313|EMBL:PZF89798.1, ECO:0000313|Proteomes:UP000248749};
RN [1] {ECO:0000313|EMBL:PZF89798.1, ECO:0000313|Proteomes:UP000248749}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13K206 {ECO:0000313|EMBL:PZF89798.1,
RC ECO:0000313|Proteomes:UP000248749};
RA Sahin N., Saygin H., Ay H.;
RT "Draft genome sequence of Salinispora sp. 13K206.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZF89798.1}.
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DR EMBL; POUB01000241; PZF89798.1; -; Genomic_DNA.
DR RefSeq; WP_111136666.1; NZ_POUB01000241.1.
DR AlphaFoldDB; A0A2W2CD74; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000248749; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:PZF89798.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000248749}.
FT DOMAIN 1..168
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 587 AA; 61930 MW; B74DE7A6DB66E971 CRC64;
MWVVATAGHV DHGKSTLVRA LTGMEPDRWA EERRRGMTID LGFAWTTLPS GGTVAFVDVP
GHERFVPNML AGVGPAPAAL VVVAADEGWM PQSAEHLAAL DAFGVSYGLL VVTRADLADP
GPALARARAE LAGTSLGAVE AVAVSAVSGA GLPQLRAALD RLAARLPVPA THVPVRLWVD
RCFTVRGSGT VVTGTLGTGR LRVGDELELA ATGEPVRVRG LHTLGAARTE VDALARVAVN
LRGTPRDRLG RGDALLTPGR FQRTDLLDVR ICGDPAADLP ATVTLHVGSA AVPTRVRPLG
PDTARLRLAR PLPLLIGDRA LLRDPGRHHV AGGVIVLDVA PPPLTRRGAA AARVAVLAGL
DGRPDLAGEL RRRRLVRAAD LRRTGVAVTG RPVVGDWLAD PDHWRQLGAR LADEVARHAR
EHPLQPGAPV ELLRRRLDLP DRALVEALVG PPLRLHAGRV TASSADALPE PVARAVARFR
AAYADRPFRA PEADHLAGLG LGPREIGAAV RAGALLRLAE NVVLLPGAPD DAVRVLAGLP
QPFTLSAARQ ALDTTRRVAV PLLELLDRRG ATRRLPDDAR VVVVTRP
//
