ID A0A2X0NSD9_9BASI Unreviewed; 1179 AA.
AC A0A2X0NSD9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 28-JAN-2026, entry version 32.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN Name=BQ5605_C011g06608 {ECO:0000313|EMBL:SGY12799.1};
GN ORFNames=BQ5605_C011G06608 {ECO:0000313|EMBL:SGY12799.1};
OS Microbotryum silenes-dioicae.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX NCBI_TaxID=796604 {ECO:0000313|EMBL:SGY12799.1, ECO:0000313|Proteomes:UP000249464};
RN [1] {ECO:0000313|EMBL:SGY12799.1, ECO:0000313|Proteomes:UP000249464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FQNC01000011; SGY12799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2X0NSD9; -.
DR Proteomes; UP000249464; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-ARBA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR FunFam; 3.30.70.270:FF:000020; Transposon Tf2-6 polyprotein-like Protein; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR050951; Retrovirus_Pol_polyprotein.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR PANTHER; PTHR37984:SF5; PROTEIN NYNRIN-LIKE; 1.
DR Pfam; PF13650; Asp_protease_2; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022750};
KW Reference proteome {ECO:0000313|Proteomes:UP000249464};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 567..752
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1108..1179
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 234..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..253
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 133535 MW; 1688755D9D008FA4 CRC64;
MSEPPEDAPP RWKLHAPSYL CRADRTLSGL RLFWSRNDRY FKREKSIKTD EDKIDTIGQL
LLDPELKVWY SSDAASHAKK TYSTFQRDLT LRALPSDYMW QHYRRLDNLR QTGDYREFST
AARDLQLELG VSLVSDTQLV RMLLLHTDEE LSQRLRLSDV IKGTGLSPDE LDASIIKTDP
STSPADLNFQ TFDAEARRLW QVIGATCASV KATTQASAKI VRPTHTSHTI KSLRTTVSPS
TPPPLPSEIR PPPMTDRERA FLKGNRGCFK CRKINAGHLS DMCTTWATAA CKVPPGWRQG
PVSSEQVVSM TDIDEGVDDE SEQLHCLRDN EYDNGTDEER CEPIFLPVKL TNDDGPVLRA
LVDTGASASF IADKEVDKLR LTQRKLQVPT SVSVAIQSHR VSHPFTEFVC VPLCTLNDRW
STQHVVLKIA PLTSLKLVLE RPFLKRHDML VDCRRRQVLV PDLTLPNKRI DLLTNCSASA
VQAGVRACLA RLEEQQAEES YLRAMEAEFR REFSDRFPVD IPPVSQYELK VFHHISLKPG
MKRPRQPTYG TPMRWRAAWR RLLEEHLAAG RLRPSSSEYS SPAFIIPKKG MDTDPSIMPR
WVNDYRILNA ATVPDCTPLP LPDKILAVSA RAQFWSKIDM TNSFFQTKMA EEDIPKTAVA
TPWGLFEWVV MPMGLSNAPA THQRRVNEAL SSLIGKSCFA YVDDITIFSN SIEEHWTQVK
EVLEALRRAD LYCSPKKTEL FRMSCVFLGH VISREGIAAD QSKFEHILEW PRPRTVTELR
GFLGLVQYLR KFINGLAQHT KPLADLTSKN ANVRLMWGAE QERHFNAIKK IVTSLPCLKP
VDHTDSADPL WVMKDASNVG ISAVLLQGQD WCKAHPVAYW SRQYISAEIN YPTHKQELLV
VVDALRQWRV NSMGVHFNVL SDHKSLKYLK TQENLSKRQA CWIECLADYD FDITYIPGGE
NAIADAMSRY SFPQGQADSI QAVVVMEVDT QLRRQRQVVE GYEADPFCQQ VKRNLDLLPG
FSCVDGVLYF EGRMVVPAVP QLWEDVLHNA HNALGHFGPR KTFQQVSRGF FWPGLRSSCE
AYVSTCNICQ RTKAATTVPS DVSHALGVPN EPMQEVALDS VGPLPKSQGF DMFLTITDRL
SGYTRLIPSR AADTAKDVAE RFHKGWHRFF GPPICMVSD
//
