UniProt: A0A2Y9G1I7

Database: UniProt
Entry: A0A2Y9G1I7_TRIMA

LinkDB:  A0A2Y9G1I7_TRIMA 
Original site:  A0A2Y9G1I7_TRIMA

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Ontology (10)   
   GO (10)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (19)   
   InterPro (13)   
   Pfam (4)   
   PROSITE (1)   
   SMART (1)   
All databases (32)   

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ID   A0A2Y9G1I7_TRIMA        Unreviewed;      1093 AA.
AC   A0A2Y9G1I7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   28-JAN-2026, entry version 38.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit alpha {ECO:0000256|RuleBase:RU362084};
GN   Name=LOC101351027 {ECO:0000313|RefSeq:XP_012415002.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_012415002.1};
RN   [1] {ECO:0000313|RefSeq:XP_012415002.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (AUG-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362084};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IIC subfamily. {ECO:0000256|ARBA:ARBA00006934,
CC       ECO:0000256|RuleBase:RU362084}.
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DR   RefSeq; XP_012415002.1; XM_012559548.1.
DR   AlphaFoldDB; A0A2Y9G1I7; -.
DR   FunCoup; A0A2Y9G1I7; 941.
DR   STRING; 127582.A0A2Y9G1I7; -.
DR   GeneID; 101351027; -.
DR   KEGG; tmu:101351027; -.
DR   InParanoid; A0A2Y9G1I7; -.
DR   OrthoDB; 3352408at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IEA:TreeGrafter.
DR   GO; GO:0030007; P:intracellular potassium ion homeostasis; IEA:TreeGrafter.
DR   GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:TreeGrafter.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:TreeGrafter.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:TreeGrafter.
DR   CDD; cd02608; P-type_ATPase_Na-K_like; 1.
DR   FunFam; 2.70.150.10:FF:000003; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR   FunFam; 3.40.1110.10:FF:000001; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR   FunFam; 3.40.50.1000:FF:000004; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR   FunFam; 1.20.1110.10:FF:000095; Sodium/potassium-transporting ATPase subunit alpha-1; 2.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR059000; ATPase_P-type_domA.
DR   InterPro; IPR050510; Cation_transp_ATPase_P-type.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR005775; P-type_ATPase_IIC.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01106; ATPase-IIC_X-K; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 2.
DR   PANTHER; PTHR43294:SF1; POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 2; 1.
DR   PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR   Pfam; PF13246; Cation_ATPase; 1.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00121; NAKATPASE.
DR   SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SMART; SM00831; Cation_ATPase_N; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362084};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU362084}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362084};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU362084};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362084};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU362084};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|RuleBase:RU362084};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362084};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362084};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362084}.
FT   TRANSMEM        168..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        201..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        362..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        392..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        853..872
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        878..897
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        918..941
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        985..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        1024..1043
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        1055..1071
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   DOMAIN          113..187
FT                   /note="Cation-transporting P-type ATPase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00831"
FT   REGION          73..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..88
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1093 AA;  120624 MW;  68C1CF7F86E179F0 CRC64;
     MAPGSACPLP PTPPPSRVLC CCTRWSSGHQ EGEPSGQRGP AGPHTSAQRC QYCTLVLFQK
     TPEIYSVELN GTKDIDKTDK GDGKEKYRGL KNKPSNCKKN HQIQEIKEEL DLNDHKLSNE
     DLEKKYGTNI ITGLSSARAA ELLARDGPNA LSPPKETPET VKFLKQMVGG FSILLWIGAI
     LCWVAYGIQY SNDPSSSLDN VYLGAVLVLV VILTGTFAYY QEAKSTNIIA SFSKMIPQQA
     LVIRDAEKKT IPSEQLVVGD IVEIKGGDQI PADIRLLSSQ GCKVDNSSLT GESEPQVRSC
     DFTHDNPLET KNMCFYSTTC LEGVATGMVI NTGDSTIIGQ IASLASGVGD EKTPIAIEIE
     HFVHIVAGVS VSIGIIFFII TVSMKYPVLD SIIFLIGVIV ANVPEGLLAT VTVTLSLTAK
     RMAKKNCLVK NLEAVETLGS TSIICSDKTG TLTQNRMTVA HLWFDNQIFM ADTSEDHSNQ
     IFDQSSGTWT SLSKIITLCN RAEFKPGQEN VPIMKKTVIG DASETALLKF SEVILGDVME
     IRKRNRKVAE IPFNSTNKFQ LSIHETDDPN DKRFLMVMKG APERILEKCS TIMINGQEQP
     LDESRATFHT AYMELGGLGE RVLGFCHLYL PADEFPETYS FDVDTMNFPT SNLCFVGLLS
     MIDPPRSTVP NAVTRCRSAG IKVIMVTGDH PITAKAIARN AGIISANSET VEDIAKCLNI
     AVEQVNKWDA KAAVVTGMEL KDMSPEQLDE LLANHSEIVF ARTSPQQKLI IVEGCQRLGA
     VVAVTGDGVN DSPALKKADI GIAMGIAGSD AAKNAADMVL LDDNFASIVT GVEEGRLIFD
     NLKKTMAYTL TKNMAMVFPF MLYTIVGFPL PIATVTTLFI DLGTDIIPFI ALAYEKAERD
     IMNRKPRHKK DRLVNKPLVL YSLLHVGVIV TLGAFVVYFT VYAQAGFRPS TLIGLRVKWE
     KDDVNDLEDS YGQEWTRYQR QYLEWTGYTA FFIAIMVQQI ANLIIRKTRR NSIFQQGLFS
     NKVIWVGIAS QIIIALILSY GLGSVTALNC TMLRVQYWFV ALPYAILIWV YDEVRKLFIR
     LYPGGWWDKN MYY
//

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