ID   A0A2Y9HZ14_NEOSC        Unreviewed;       536 AA.
AC   A0A2Y9HZ14;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   28-JAN-2026, entry version 36.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|RefSeq:XP_021556806.1, ECO:0000313|RefSeq:XP_021556807.1};
GN   Name=SOCS5 {ECO:0000313|RefSeq:XP_021556806.1,
GN   ECO:0000313|RefSeq:XP_021556807.1};
OS   Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC   Monachinae; Monachini; Neomonachus.
OX   NCBI_TaxID=29088 {ECO:0000313|Proteomes:UP000248481, ECO:0000313|RefSeq:XP_021556806.1};
RN   [1] {ECO:0000313|RefSeq:XP_021556806.1, ECO:0000313|RefSeq:XP_021556807.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_021556806.1,
RC   ECO:0000313|RefSeq:XP_021556807.1};
RG   RefSeq;
RL   Submitted (APR-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_021556806.1; XM_021701131.1.
DR   RefSeq; XP_021556807.1; XM_021701132.2.
DR   AlphaFoldDB; A0A2Y9HZ14; -.
DR   STRING; 29088.A0A2Y9HZ14; -.
DR   GeneID; 110590354; -.
DR   KEGG; nsu:110590354; -.
DR   CTD; 9655; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000248481; Chromosome 10.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248481};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          381..476
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          471..520
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          113..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  60982 MW;  15FAF735A1188F0B CRC64;
     MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSSRCLSV KERNISIGDL APQQQSSPLR
     ENVALQLGLS PSKNPSRRNQ NCAAEIPPIV EISIDKDNDS CVTPGARLAR RDSYSRHAPW
     GGKKKHSCST KTQSSLDTDK KFGRTRSGLQ RRERRCGVSS AHDTDSVSSR AVGSRSLRQR
     LRDTVGLCFP TRTYSKQSKP LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV
     SPHSTFFDTF DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
     PKLAPGMTEV SGDSTAIPQA NCDSEEDTTT LCLQSRRQKQ RQVSGDSHAH VSRQGAWKVH
     TQIDYIHCLV PDLLQIIGNP CYWGVMDRYE AEALLEGKPE GTFLLRDSAQ EDYLFSVSFR
     RYNRSLHARI EQWNHNFSFD AHDPCVFHSS TVTGLLEHYK DPSSCMFFEP LLTISLNRTF
     PFSLQYICRA VICRCTTYDG IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK
//