ID A0A2Y9HZJ3_NEOSC Unreviewed; 440 AA.
AC A0A2Y9HZJ3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|RefSeq:XP_021557063.1};
GN Name=SOCS4 {ECO:0000313|RefSeq:XP_021557063.1};
OS Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Monachinae; Monachini; Neomonachus.
OX NCBI_TaxID=29088 {ECO:0000313|Proteomes:UP000248481, ECO:0000313|RefSeq:XP_021557063.1};
RN [1] {ECO:0000313|RefSeq:XP_021557063.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_021557063.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_021557063.1; XM_021701388.1.
DR AlphaFoldDB; A0A2Y9HZJ3; -.
DR STRING; 29088.A0A2Y9HZJ3; -.
DR GeneID; 110590590; -.
DR KEGG; nsu:110590590; -.
DR CTD; 122809; -.
DR InParanoid; A0A2Y9HZJ3; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000248481; Chromosome 9.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000248481};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 287..382
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 377..426
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..10
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 50331 MW; 971538DB01CE1D6B CRC64;
MAENSESISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESCSDAE TVNAVEKTEV
PLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSG RHSSGLPSKR
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINPKSNE WVNTDLSQSE LRDGQLKQRR
NVEEEVNCFS HSNVQPCVIT TNSASCRGGP VTGSVMNLVS NNSIEDSDMD SDDEIITLCT
SSRKRNKPKW EMDEEILQLE TPPKYHTQID YVHCLVPDLL QINNNPCYWG VMDKYAAEAL
LEGKPEGTFL LRDSAQEDYL FSVSFRRYSR SLHARIEQWN HNFSFDAHDP CVFHSPDITG
LLEHYKDPSA CMFFEPLLST PLIRTFPFSL QHICRTVICN CTTYDGIDAL PIPSSMKLYL
KEYHYKSKVR VLRIDATEQC
//
