ID A0A2Y9L8Z3_ENHLU Unreviewed; 197 AA.
AC A0A2Y9L8Z3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Kinetochore protein Spc24 {ECO:0000256|ARBA:ARBA00013690, ECO:0000256|RuleBase:RU368011};
GN Name=LOC111162479 {ECO:0000313|RefSeq:XP_022382637.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022382637.1};
RN [1] {ECO:0000313|RefSeq:XP_022382637.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022382637.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. Required for kinetochore integrity and the
CC organization of stable microtubule binding sites in the outer plate of
CC the kinetochore. The NDC80 complex synergistically enhances the
CC affinity of the SKA1 complex for microtubules and may allow the NDC80
CC complex to track depolymerizing microtubules.
CC {ECO:0000256|ARBA:ARBA00045419}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80/HEC1,
CC CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two
CC subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each
CC subcomplex is formed by parallel interactions through the coiled-coil
CC domains of individual subunits. Formation of a tetrameric complex is
CC mediated by interactions between the C-terminal regions of both
CC subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions
CC of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80
CC complex has an elongated rod-like structure with globular domains at
CC either end. {ECO:0000256|ARBA:ARBA00064545}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU368011}.
CC Chromosome, centromere, kinetochore {ECO:0000256|RuleBase:RU368011}.
CC -!- SIMILARITY: Belongs to the SPC24 family.
CC {ECO:0000256|ARBA:ARBA00007804, ECO:0000256|RuleBase:RU368011}.
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DR RefSeq; XP_022382637.1; XM_022526929.1.
DR AlphaFoldDB; A0A2Y9L8Z3; -.
DR GeneID; 111162479; -.
DR CTD; 147841; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0031262; C:Ndc80 complex; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IEA:TreeGrafter.
DR CDD; cd11565; RWD_Spc24; 1.
DR FunFam; 3.30.160.570:FF:000001; SPC24, NDC80 kinetochore complex component; 1.
DR Gene3D; 3.30.160.570; Ncd80 complex, Spc24 subunit; 1.
DR InterPro; IPR013252; Ndc80_Spc24.
DR PANTHER; PTHR22142; -; 1.
DR PANTHER; PTHR22142:SF2; KINETOCHORE PROTEIN SPC24; 1.
DR Pfam; PF08286; Spc24; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368011};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU368011};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368011};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368011};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368011};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368011};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368011};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT COILED 31..131
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 197 AA; 22674 MW; 501A8CE55B5632C4 CRC64;
MAAFRDMEEV SQGLLSLLGA NRAEAQQRRL LGRHEQVVER LLETQDNAEQ RLREILAMEE
EVAQSLLDAK ERAHQGGVEL QQLQEELQKA GEEDTRVKAR LRQLTQELEE LKEIEASLER
QEREVDEDTT VTIPSAVYVA QLYHRISKIE WDYESEAGMV KGIHHGPSVA QPLHLDSTQL
SKKFISDYLW SLVDTDW
//
