ID A0A2Y9PGG0_DELLE Unreviewed; 700 AA.
AC A0A2Y9PGG0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 28-JAN-2026, entry version 32.
DE RecName: Full=Zinc finger protein 750 {ECO:0000256|ARBA:ARBA00040216};
GN Name=ZNF750 {ECO:0000313|RefSeq:XP_022444924.1,
GN ECO:0000313|RefSeq:XP_030617942.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022444924.1};
RN [1] {ECO:0000313|RefSeq:XP_022444924.1, ECO:0000313|RefSeq:XP_030617942.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022444924.1,
RC ECO:0000313|RefSeq:XP_030617942.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022444924.1; XM_022589216.2.
DR RefSeq; XP_030617942.1; XM_030762082.1.
DR AlphaFoldDB; A0A2Y9PGG0; -.
DR STRING; 9749.A0A2Y9PGG0; -.
DR GeneID; 111182648; -.
DR KEGG; dle:111182648; -.
DR CTD; 79755; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0061436; P:establishment of skin barrier; IEA:Ensembl.
DR GO; GO:0044091; P:membrane biogenesis; IEA:Ensembl.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 6..57
FT /note="Zinc finger protein 750-like zinc finger"
FT /evidence="ECO:0000259|Pfam:PF15269"
FT REGION 62..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 75240 MW; D68F72F1B60BD53B CRC64;
MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
RIPKCSKPNS SDPKPTNQSD PMAKPTSSKP VPSGLSHLDT KLQHGLAKDD IKENVDLHAC
GPHRCPGQKP TLHKEAAPLS PAPEATAGTQ PVLEGTTRPS AFMPVGEHRL KGQELTEAPE
ALTLTQPPAK AASFHTKSAF HAPGYAWKAG SPFLTPEFPH KIPSTKGFGA TSPYVHPTIA
EYPPHFYTEH GLATIYSPYL LAGNSPECDS PLLSIYGAQD QRHFLPHPGP IPKHLNPAPS
TYDHYRFFQQ YHSNLPIPYG FYRPESAFSS YGLRPPPVDG ISQDQSSHLL EEAALAYPAW
SPSKLNSHKK HTEFEKESLT PEAKDLSRDG QRDTEGTKMS PRAGSAATGS PGRPSPTNFT
QTSQPCAGLC SLLDMPASGA PGSLHPPEQS LTAFKPVKKN TERPHSQAPE NRAASPESLE
AVNADALAQM GSLEAAPSSP EDDSRAAPLN LSTKPEAEPA TIHTTAYGEF VEPQDAPLNL
SVKDPCNALT SRPSVRSRPR GAEPAAAPTP TPAPQLETAS SGAGPDPSSV EIPVPSPAGK
AQDTRSADSD EQKQTAAVAL CQLAAYSPGN VEPAAQEPAC QVDAPTPRAP ESQEAQCDLR
PKGQKRTSPR DAGKAQQGTK KAKPSDTARV FTLRKRTRVS
//
