ID A0A315VNL8_GAMAF Unreviewed; 916 AA.
AC A0A315VNL8;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 28-JAN-2026, entry version 31.
DE RecName: Full=Platelet-derived growth factor receptor-like protein {ECO:0000256|ARBA:ARBA00019671};
GN ORFNames=CCH79_00016150 {ECO:0000313|EMBL:PWA24639.1};
OS Gambusia affinis (Western mosquitofish) (Heterandria affinis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Gambusia.
OX NCBI_TaxID=33528 {ECO:0000313|EMBL:PWA24639.1, ECO:0000313|Proteomes:UP000250572};
RN [1] {ECO:0000313|EMBL:PWA24639.1, ECO:0000313|Proteomes:UP000250572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NE01/NJP1002.9 {ECO:0000313|EMBL:PWA24639.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PWA24639.1};
RX PubMed=29703783;
RA Hoffberg S.L., Troendle N.J., Glenn T.C., Mahmud O., Louha S., Chalopin D.,
RA Bennetzen J.L., Mauricio R.;
RT "A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia
RT affinis Using a Chicago Library.";
RL G3 (Bethesda) 8:1855-1861(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] +
CC ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:20101, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:61978, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00051243};
CC -!- SUBUNIT: Forms a complex composed of PDGFRL, TNK2 and GRB2.
CC {ECO:0000256|ARBA:ARBA00011360}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA24639.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NHOQ01001398; PWA24639.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A315VNL8; -.
DR STRING; 33528.ENSGAFP00000032706; -.
DR Proteomes; UP000250572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR042495; PDGFRL.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR15360; PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE; 1.
DR PANTHER; PTHR15360:SF4; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF25305; Ig_PDGFR_d4; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000250572};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 571..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 272..362
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 377..466
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 872..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 100873 MW; 493CCF8DFDAF6B1C CRC64;
MSSDWTAGFW HSEGFVPVGL KELNCFNRRC LQENPPEPES RKLSKQSHRD GTVLDPVLVR
LMRPAAMTAS IRATTGSLSL LHFLLGVFLS RPEGGVALEL LPSSPEVLLQ SQSNFSVVCS
GWSEVKWRLP QDADGGPEVL VRVDGSSRIL QLLGATWRSS GRYTCEEPSA DQSRTVDVFI
PGQGPEQWFV PQSSSQVYKH SEEGTIPCVV SNPKLNVSLF ERPGRTAVGG VRYEPALGFM
GRLNDAGHIC VATDGDQERE SQVFYVFTVL EPKQMEMELS VSSQVLKQGE VLTMNCSVKD
VDMAFFTWTF PRRQEVEPLT DILSNEIRSF INISKATESD SGVYVCKAQD SQFRWTVRKN
ITITVLDHGY VYLWPSGETN ISSLVHHTVE LKVEGDAHPT PTFTWARPNQ TIAIETSSVN
TTHLTSSRYV STLTLHQVQL DQAGTYTATA SNEDSREDVM FYLQVTAPPR ILSLSEVDKK
DILCVSEGVP TPSVAWYTCP RLIRCSNLSD GWRSQLGALE QDVTTVIEGG GTLVKSVLTL
KTLDSVSAVR CEATNAAGGR ARDLRVLRTS LLSQVVVLVA VLVLVIIGPI YLITEFCRHG
NLLSYLKRNK DTFGEVDMPS RSNSDGGYMD MNQDGRGRYV PLKELKDTEQ GTGHAPTDHQ
TAPLLLLSDS PFLTMEDLLS FSFQVAQAMD FLSSRKRCWD EDPLSRPSFS SLVVAVGNML
PADYRQRYAQ LTEDFLRGDG PAILQSRRSL SRTTKTETET DVQLDRNSSH CAARLQEAEL
GFHFTGSPSS DVKERLLEAE PEDSGPSHNA YIMPVVTMET SSSTALDAVS PLLSGPADIF
ETQEVTSPPE APAEAEEESC LHTRHVALLR LPAPDPVLTQ DRAGRDPPSS SVLNPIPVSS
GVIGDENNKH CHNFNA
//
