ID A0A315ZXZ4_9FIRM Unreviewed; 638 AA.
AC A0A315ZXZ4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SAMN05216529_10792 {ECO:0000313|EMBL:SUQ14638.1};
OS Faecalicatena contorta.
OC Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
OC Lachnospiraceae; Faecalicatena.
OX NCBI_TaxID=39482 {ECO:0000313|EMBL:SUQ14638.1, ECO:0000313|Proteomes:UP000254051};
RN [1] {ECO:0000313|Proteomes:UP000254051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NLAE-zl-C134 {ECO:0000313|Proteomes:UP000254051};
RA Varghese N., Submissions S.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; UHJJ01000007; SUQ14638.1; -; Genomic_DNA.
DR RefSeq; WP_109711712.1; NZ_QGDS01000007.1.
DR AlphaFoldDB; A0A315ZXZ4; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000254051; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SUQ14638.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000254051}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 638 AA; 72154 MW; 7FA7A0D2BE5C7F60 CRC64;
MKHIIIGTAG HIDHGKTTLI KALTGRNTDR WEEEQRRGIT IDLGFTYFDL KNGNRVGIID
VPGHEKFINN MVAGVVGMDL VLLVVAADEG IMPQTREHMD ILEMLGVKKS ILVLNKCDIV
DEEWLELVEE EIKEELNGTF LEHAPVVKVS AATGQGISQL VETIEHLSEE EVEAKDIHTI
PRLPVDRVFS ISGFGTIVTG TLVSGMIQKE DTLEMFPNGQ ECKIRSIQVH GETVDKCYAG
QRVAINISNL KKKEIKRGCV LAPVGSMKDS RLMDVKLEVL DSTMRMLSNN MRLHFFSGTS
EVLCRAVLLG DETLGPGDSG YVQLRMEEDV AFRRGDRFIV RFYSPMETIG GGVILEPNAG
KKKRFSPEVI ESLKQKESGS ATDVIELHVK EYRDTMAAVS ELAKLTALSR EETEAAVEEL
ESQGLVRTFL MKKDIYVWHK ADEYEYRERI LEALRNFVKK YPYRYGMSKA EVHSTFMKKV
KPNLFDKYIE LLAEQGFLAR HEEYLAPAEY KVSKDETYEK VRRKLFSVLK PARYDFVKVA
EISFDSVPLQ IVEDILLLMA DEGEILKVAD GMYTLSAYME EAREKIIEKL KADGKITIAE
IRDMFGTSRK SAKPILEYMD SIKVTRKTGA ESERISNL
//
