ID A0A317FZ77_BUTFI Unreviewed; 626 AA.
AC A0A317FZ77;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203};
GN ORFNames=CPT75_05175 {ECO:0000313|EMBL:PWT26557.1};
OS Butyrivibrio fibrisolvens.
OC Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
OC Lachnospiraceae; Butyrivibrio.
OX NCBI_TaxID=831 {ECO:0000313|EMBL:PWT26557.1, ECO:0000313|Proteomes:UP000245488};
RN [1] {ECO:0000313|EMBL:PWT26557.1, ECO:0000313|Proteomes:UP000245488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INBov1 {ECO:0000313|EMBL:PWT26557.1,
RC ECO:0000313|Proteomes:UP000245488};
RA Rodriguez Hernaez J., Rivarola M., Paniego N., Cravero S., Ceron Cucchi M.,
RA Martinez M.C.;
RT "High-quality draft genome sequence of Butyrivibrio fibrisolvens INBov1,
RT isolated from cow rumen.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWT26557.1}.
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DR EMBL; NXNG01000001; PWT26557.1; -; Genomic_DNA.
DR RefSeq; WP_110072344.1; NZ_CM009896.1.
DR AlphaFoldDB; A0A317FZ77; -.
DR Proteomes; UP000245488; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR FunFam; 3.40.1440.10:FF:000001; UvrABC system protein C; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR050066; UvrABC_protein_C.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; NF001824; PRK00558.1-5; 1.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF22920; UvrC_RNaseH; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP000245488};
KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW Rule:MF_00203}.
FT DOMAIN 17..96
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 208..243
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 259..501
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
SQ SEQUENCE 626 AA; 72503 MW; 31632D526EBE8087 CRC64;
MEENRFDVKE ELKKLPHSPG VYIMHDADDV IMYVGKAIDL HKRVQSYFRK IVGRGPQIDQ
MVSRIARFEY IVTDSELEAL VLENNLIKEN RPRYNTLLKD DKTYPYIKVT VQEEYPRILF
SRLMRKDKAR YFGPFTSAQA VKSTIDLINK IYGLRTCNRS LPKDIGQQRP CLNYYMGRCC
GPCTGKVSQE EYRQHIDKAL DFLSGNYNVI LKELEDKMYK ASEEMDFEKA AHFRDLLSDV
RSVAQKQKMT DSSMEDKDII AIASDESDAV IQVFFVRDGR LIGREHFYMT HVGGNPQEEI
LLDFVKQFYS GTPFIPRELM LPVAIEDQEV IEKWLSGRKG SRMYITVPER GQKEKLMELA
AENASLVLSK DRERIKREEG RTIGAVKEIE KILGMKNLVR MEAYDISNIS GFANVGSMVV
FEKGKPKKSD YRKFRIKSVE GPNDYACMHE VLTRRLLHGL EERQDMELRN IDAQYGSFTR
FPDLILMDGG RGQVNICLQV LDELGINIPV CGMVKDDNHR TRGLYFNNVE LPIDTRSEGF
KLITRIQDEA HRFAIEYHRS LRSKAQVRSV LDDIPGIGAA RRKALMRDFE SIKDIKEASV
EELMKVPELR EKEALAVYEF FHKEEK
//
