ID A0A326UCW7_THEHA Unreviewed; 665 AA.
AC A0A326UCW7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 28-JAN-2026, entry version 27.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=EI42_03824 {ECO:0000313|EMBL:PZW26672.1};
OS Thermosporothrix hazakensis.
OC Bacteria; Bacillati; Chloroflexota; Ktedonobacteria; Ktedonobacterales;
OC Thermosporotrichaceae; Thermosporothrix.
OX NCBI_TaxID=644383 {ECO:0000313|EMBL:PZW26672.1, ECO:0000313|Proteomes:UP000248806};
RN [1] {ECO:0000313|EMBL:PZW26672.1, ECO:0000313|Proteomes:UP000248806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1881 {ECO:0000313|EMBL:PZW26672.1,
RC ECO:0000313|Proteomes:UP000248806};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZW26672.1}.
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DR EMBL; QKUF01000014; PZW26672.1; -; Genomic_DNA.
DR RefSeq; WP_111324175.1; NZ_BIFX01000001.1.
DR AlphaFoldDB; A0A326UCW7; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000248806; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:PZW26672.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000248806}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 665 AA; 73669 MW; E4FFB9B64C97DBE9 CRC64;
MSCIGTAGHI DHGKSTLVQA LTGIDPDRLA EEKARGMTID LGFAWLTLPG GREVSIVDVP
GHESFIKNML AGTGGIDAAL LVVAADEGIM PQTREHLAIL DLLRVPRGVV ALTKADLVDE
EWLELVREEV SAQLRPTTLA QAPILPVSSY TREGLPELLS TLDRILSEEE VRQDIARPRL
FVDRVFTLTG FGTVVTGTLL DGTLRVGQEV EILPAGLRTR IRGMQTHKQA VEVARPGSRV
ALNLANIARS DVRRGDVVAL PGQLRPVQLF DARIRLLPDA PRPLTHNTEV EVFSGSQEIP
AKVRLLDVET LQPGASAWAQ FRLSRPAVLV RRDPFVLRIP SPSMTIGGGE VVDTRPRYHR
RFQASVLETL EQMLHGTPED LVLAALETRR VGAKKGASAS GGKGYELRDL ARQCNLAEDV
TQQICDTLLS ERRVRKIGNF WVAQTVWEAL VEESVRLVSD FHRRYPLRSG LSKEEWRTRL
HLTPRLAADV FATLQREGVL EQGEIPGTGG LSETRGAGTV HLPGYAPQYT EQQKKQVVQL
LERFRASPFT PPTRAEAEKI AEAEVVTALI EQGVLVKIGD GLLFLRETYE EMLRKVLTYL
YQHGTMTVAE ARDLLGTTRK YILPVLEHMD ILRITRRNGD ERVPGPNAAL LVPDQSEFLE
RKEEK
//
