ID A0A330L0B5_9BACT Unreviewed; 267 AA.
AC A0A330L0B5;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=hydroxymethylpyrimidine kinase {ECO:0000256|ARBA:ARBA00012135};
DE EC=2.7.1.49 {ECO:0000256|ARBA:ARBA00012135};
GN Name=thiD {ECO:0000313|EMBL:SPP63205.1};
GN ORFNames=NITLEN_10291 {ECO:0000313|EMBL:SPP63205.1};
OS Nitrospira lenta.
OC Bacteria; Pseudomonadati; Nitrospirota; Nitrospiria; Nitrospirales;
OC Nitrospiraceae; Nitrospira.
OX NCBI_TaxID=1436998 {ECO:0000313|EMBL:SPP63205.1, ECO:0000313|Proteomes:UP000248168};
RN [1] {ECO:0000313|Proteomes:UP000248168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucker S., Sakoula D.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004948}.
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DR EMBL; OUNR01000001; SPP63205.1; -; Genomic_DNA.
DR RefSeq; WP_121987773.1; NZ_OUNR01000001.1.
DR AlphaFoldDB; A0A330L0B5; -.
DR FunCoup; A0A330L0B5; 452.
DR InParanoid; A0A330L0B5; -.
DR OrthoDB; 9810880at2; -.
DR Proteomes; UP000248168; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008902; F:hydroxymethylpyrimidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01169; HMPP_kinase; 1.
DR FunFam; 3.40.1190.20:FF:000003; Phosphomethylpyrimidine kinase ThiD; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SPP63205.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248168};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SPP63205.1}.
FT DOMAIN 16..260
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
SQ SEQUENCE 267 AA; 28176 MW; 925C448A468AA6F4 CRC64;
MTARTLKQVL TIAGSDSGGG AGIQADLKSM SANGVFAMSV ITAVTAQNTE DVTDVFELPT
SIIGSQLDAV FDDFEVSAVK TGMLSSTAIV ELVAKMLAVQ KVANLVVDPV MVSKSGRALL
KPDAIDALKK LLFPLALVVT PNIHEAQQLS GIAIGNLADA RRAAKIIHGF GCQYVLIKGG
HLLAERGTDL LYDGRFFNIY KGEFIDTPHT HGTGCTFASA LAAQLARGKA MTDAVQAAKT
YLTETIRHSL AIGHGTGPTN HFYFLET
//
