ID A0A337SI67_FELCA Unreviewed; 88 AA.
AC A0A337SI67;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 18-JUN-2025, entry version 25.
DE RecName: Full=FXYD domain-containing ion transport regulator {ECO:0000256|RuleBase:RU364131};
GN Name=LOC101088462 {ECO:0000313|Ensembl:ENSFCAP00000046742.1};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000046742.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000046742.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000046742.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000046742.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000046742.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000046742.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000046742.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Associates with and regulates the activity of the
CC sodium/potassium-transporting ATPase (NKA) which catalyzes the
CC hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions
CC across the plasma membrane. Increases the apparent affinity of the
CC transporter for Na(+) and increases NKA activity.
CC {ECO:0000256|ARBA:ARBA00054079}.
CC -!- SUBUNIT: Regulatory subunit of the sodium/potassium-transporting ATPase
CC which is composed of a catalytic alpha subunit, a non-catalytic beta
CC subunit and a regulatory subunit. The regulatory subunit, a member of
CC the FXYD protein family, modulates the enzymatic activity in a
CC tissue- and isoform-specific way by changing affinities of the Na+/K+-
CC ATPase toward Na(+), K(+) or ATP. {ECO:0000256|ARBA:ARBA00066169}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00023768}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00023768}.
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000256|ARBA:ARBA00005948,
CC ECO:0000256|RuleBase:RU364131}.
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DR EMBL; AANG04001014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_044912636.1; XM_045056701.1.
DR AlphaFoldDB; A0A337SI67; -.
DR STRING; 9685.ENSFCAP00000046742; -.
DR Ensembl; ENSFCAT00000056763.1; ENSFCAP00000046742.1; ENSFCAG00000043408.1.
DR GeneID; 101088462; -.
DR GeneTree; ENSGT00940000153062; -.
DR InParanoid; A0A337SI67; -.
DR OMA; SYDWESL; -.
DR OrthoDB; 8895254at2759; -.
DR Proteomes; UP000011712; Chromosome A1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017080; F:sodium channel regulator activity; IBA:GO_Central.
DR GO; GO:1903278; P:positive regulation of sodium ion export across plasma membrane; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IEA:InterPro.
DR CDD; cd20322; FXYD4; 1.
DR FunFam; 1.20.5.780:FF:000007; FXYD domain-containing ion transport regulator; 1.
DR Gene3D; 1.20.5.780; Single helix bin; 1.
DR InterPro; IPR047283; FXYD4.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR PANTHER; PTHR14132:SF10; FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 4; 1.
DR PANTHER; PTHR14132; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA; 1.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU364131};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364131};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Sodium/potassium transport {ECO:0000256|ARBA:ARBA00022607};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364131};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364131};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU364131}.
FT TRANSMEM 40..58
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364131"
SQ SEQUENCE 88 AA; 9502 MW; 217CE5C7C4CAD4E8 CRC64;
MKRVTWGLLL TRAGLPALET NDLVDKDSPF SYDWESLELG GMIVGGLLCI AGILIALSRS
CKCKYSKKHS PLPERAAPLI TPDPASTC
//
