ID A0A341AHX3_NEOAA Unreviewed; 371 AA.
AC A0A341AHX3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE RecName: Full=Class E basic helix-loop-helix protein 40 {ECO:0000256|ARBA:ARBA00040229};
DE AltName: Full=Class B basic helix-loop-helix protein 2 {ECO:0000256|ARBA:ARBA00042387};
GN Name=BHLHE41 {ECO:0000313|RefSeq:XP_024589208.1};
OS Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
OS (Neophocaena phocaenoides subsp. asiaeorientalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Phocoenidae; Neophocaena.
OX NCBI_TaxID=1706337 {ECO:0000313|Proteomes:UP000252040, ECO:0000313|RefSeq:XP_024589208.1};
RN [1] {ECO:0000313|RefSeq:XP_024589208.1}
RP IDENTIFICATION.
RC TISSUE=Meat {ECO:0000313|RefSeq:XP_024589208.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBUNIT: Homodimer. Heterodimer with BHLHE41/DEC2. Interacts with
CC TCF3/E47. Interacts with ubiquitin-conjugating enzyme UBE2I/UBC9.
CC Interacts with HDAC1, SUMO1, RXRA and BMAL1.
CC {ECO:0000256|ARBA:ARBA00064243}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_024589208.1; XM_024733440.1.
DR AlphaFoldDB; A0A341AHX3; -.
DR FunCoup; A0A341AHX3; 86.
DR STRING; 1706337.A0A341AHX3; -.
DR GeneID; 112391894; -.
DR KEGG; nasi:112391894; -.
DR CTD; 79365; -.
DR InParanoid; A0A341AHX3; -.
DR Proteomes; UP000252040; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR CDD; cd19750; bHLH-O_DEC2; 1.
DR FunFam; 4.10.280.10:FF:000020; class E basic helix-loop-helix protein 40; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000252040};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 44..99
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 131..166
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 229..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 40343 MW; 36C6D6CCB7BA4D21 CRC64;
MDEGIPHLQE RQLLEHRDFI GLDYPSLYMC KPKRSMKRDD SKDTYKLPHR LIEKKRRDRI
NECIAQLKDL LPEHLKLTTL GHLEKAVVLE LTLKHLKALT ALTEQQHQKI IALQNGERSL
KSPIQSDLDA FHSGFQTCAK EVLQYLARFE SWTPREPRCV QLINHLHAVA TQFLPTPQLL
TQQVPLSKGT GVPSAATPAG SGAAPCLERA GQKLEPLAHC VPVIQRTQPS AELAAENDTD
TDSGYGGEAE ARPDREKGKG AGASRVTIKQ EPPGEDSPAP KRMKLDSRFF FAAAAAAAAF
PCLSSVLSPP PEKAAAAAAA TLLPHEVAPP GALHPPLPHG RTHLSFAGRS EPGNPESSAQ
EDPSQPGKEA P
//
