ID A0A341B2D8_NEOAA Unreviewed; 817 AA.
AC A0A341B2D8;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 28-JAN-2026, entry version 31.
DE SubName: Full=Sp110 nuclear body protein isoform X2 {ECO:0000313|RefSeq:XP_024596329.1};
GN Name=SP110 {ECO:0000313|RefSeq:XP_024596329.1};
OS Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
OS (Neophocaena phocaenoides subsp. asiaeorientalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Phocoenidae; Neophocaena.
OX NCBI_TaxID=1706337 {ECO:0000313|Proteomes:UP000252040, ECO:0000313|RefSeq:XP_024596329.1};
RN [1] {ECO:0000313|RefSeq:XP_024596329.1}
RP IDENTIFICATION.
RC TISSUE=Meat {ECO:0000313|RefSeq:XP_024596329.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
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DR RefSeq; XP_024596329.1; XM_024740561.1.
DR AlphaFoldDB; A0A341B2D8; -.
DR GeneID; 112396735; -.
DR CTD; 3431; -.
DR Proteomes; UP000252040; Unplaced.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProtKB-ARBA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd05501; Bromo_SP100C_like; 1.
DR CDD; cd15626; PHD_SP110_140; 1.
DR FunFam; 1.20.920.10:FF:000028; Nuclear autoantigen Sp-100; 1.
DR FunFam; 3.30.40.10:FF:000294; Nuclear autoantigen Sp-100; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR004865; HSR_dom.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR000770; SAND_dom.
DR InterPro; IPR043563; Sp110/Sp140/Sp140L-like.
DR InterPro; IPR030411; Sp140_Bromo.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46386; NUCLEAR BODY PROTEIN SP140; 1.
DR PANTHER; PTHR46386:SF7; SP110 NUCLEAR BODY PROTEIN; 1.
DR Pfam; PF03172; HSR; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF01342; SAND; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00258; SAND; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
DR PROSITE; PS51414; HSR; 1.
DR PROSITE; PS50864; SAND; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000252040};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 1..105
FT /note="HSR"
FT /evidence="ECO:0000259|PROSITE:PS51414"
FT DOMAIN 506..587
FT /note="SAND"
FT /evidence="ECO:0000259|PROSITE:PS50864"
FT DOMAIN 638..684
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 141..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..265
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..427
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 817 AA; 92898 MW; D1B0A20B5D512B91 CRC64;
MTRTLKEVLL QHFIHQKLEI AYAINKPFPF FEGLRDNFFI TERLYQESLE AYRNMVPVSR
VVYNILTQLE NTFSLSFLET LFSRINLSEY PNLMTTLKSF KRVVTSNGGW GRITTIPLEA
AANPAGRSSV WALLPLPTCQ HPPSSRPPCS PSVSEPGAPA QPSAEILHEH PSPADLTVAL
PGIIQEGRLT PVSSDNLIPQ IKDKEDTQEM SCAPSGPVPV IRDDASEHSD PKELQEAPRA
PPSKKGKKRK RSIWLTPRKR HQKKSLPREA QSPWVREKNS LLSFTTSSTR QRFPRTQTHR
LEKRADEIFL WAALPGHGIQ TTLHVAEQVT HREDDSTRNT KVMTRAKKRR TECAQTPAPE
EVSDDTSEMD EGKRPQEPPS TPPRLTHGKD PMDKGSKLPL EESPGEKRRK RKIHSWSSSK
KRQKKSLPRG SASPGRRTQE MLQVVEQVAE RKDDSTRRSK VMTRAQKARA ERAPKPAPEE
KERIKDVCSS ATSCHRNIPI KEKPEDETLD FHSPKLPVTC GEAKGILYKE KMKQGPSEKC
IQNEKGLWFT PREFEIEGKR KQSKNWKRSV LCRGKTLEQL LEKGLLLCPP RKSLKREHNV
RDCSLSCQHV CLARRTADED SSDPGTGSLG ANLTQENSRE CEVCCRGGPL LCCDTCPRAF
HEDCHIPPAE AKRSAWSCTF CRMKESSGSQ QCLGESGVLA RQMQPEEQLK CEFLLLKAYC
HPQSSFFTET PCNIRDYGEP FREAMWLDLV KERLAEKVYT VAWFLRDMRL IFRNHKTFYK
ASDFGQVGLD LEAEFEKDLK EVLIFHEASE NSFQVPP
//
