ID A0A345XJ20_9ACTN Unreviewed; 327 AA.
AC A0A345XJ20;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 18-JUN-2025, entry version 18.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:AXK31636.1};
GN ORFNames=DVA86_02220 {ECO:0000313|EMBL:AXK31636.1};
OS Streptomyces armeniacus.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=83291 {ECO:0000313|EMBL:AXK31636.1, ECO:0000313|Proteomes:UP000254425};
RN [1] {ECO:0000313|EMBL:AXK31636.1, ECO:0000313|Proteomes:UP000254425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15676 {ECO:0000313|EMBL:AXK31636.1,
RC ECO:0000313|Proteomes:UP000254425};
RA Labana P., Gosse J.T., Boddy C.N.;
RT "Draft genome of the type strain Streptomyces armeniacus ATCC 15676.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; CP031320; AXK31636.1; -; Genomic_DNA.
DR RefSeq; WP_208875298.1; NZ_CP031320.1.
DR AlphaFoldDB; A0A345XJ20; -.
DR KEGG; sarm:DVA86_02220; -.
DR Proteomes; UP000254425; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 3.40.50.720:FF:000307; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF005089; PRK06522.1-4; 1.
DR PANTHER; PTHR21708:SF45; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000254425}.
FT DOMAIN 3..169
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 196..314
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 327 AA; 34617 MW; 3A683A15E8B9ACD1 CRC64;
MRVAVVGAGA IGAYVGAVLD RAGADVHLIA RGPHLAAMRR HGVQVLSPRG DFTAHVHATD
DPSAIGPVDY VFLGLKAHAY AACGPLVHPL LHADTAVVAA QNGIPWWYFH ALKGPYEGRC
VESVDPGGAV SRVLPPERAV GCVVYAATEL EAPGVVRHLE GTRFSVGEPD STVSARCLAF
SEAMRAGGLK CPVEADLRND IWIKLLGNIA FNPLSALSRA TMAQICRHQD TRALVATMMR
ETLAVAEAVG CRPEISVERR LAGAERVGEH KTSTLQDLER GRPMELDVLL AAVVELAALT
RTPVPKLCAI HAVTDLLAQT TYGSDAA
//
