ID   A0A367Y4E5_9ASCO        Unreviewed;       356 AA.
AC   A0A367Y4E5;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   05-FEB-2025, entry version 16.
DE   RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=Cantr_08195 {ECO:0000313|EMBL:RCK60756.1};
OS   Candida viswanathii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes;
OC   Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK60756.1, ECO:0000313|Proteomes:UP000253472};
RN   [1] {ECO:0000313|EMBL:RCK60756.1, ECO:0000313|Proteomes:UP000253472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK60756.1,
RC   ECO:0000313|Proteomes:UP000253472};
RA   Ahn J.;
RT   "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT   Korea University).";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC       {ECO:0000256|ARBA:ARBA00007870}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCK60756.1}.
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DR   EMBL; QLNQ01000026; RCK60756.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A367Y4E5; -.
DR   STRING; 5486.A0A367Y4E5; -.
DR   OrthoDB; 3609at2759; -.
DR   Proteomes; UP000253472; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:InterPro.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR   FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR   Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR003710; ApbA.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR051402; KPR-Related.
DR   InterPro; IPR013332; KPR_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR00745; apbA_panE; 1.
DR   PANTHER; PTHR21708:SF30; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR   PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253472}.
FT   DOMAIN          6..162
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          197..319
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
SQ   SEQUENCE   356 AA;  39723 MW;  5D5F5287D4506C0F CRC64;
     MSKPKVLVVG SGGVGAISAL SLTDNNKAEV TLVVRSDYDL ISAQGYTIDS VTYGKLTNWR
     PHHLARSVAH AQQEQGPFDY ILLTTKNIPD GPTTCEEIIR PAVVTGNEVI ILLQNGLGIE
     NPMFEAYPGH VILSGISHIG STYINGHVTN PGKDFVYLGD FKPEGERQAH SLEKIEEFIT
     LYQNEDPEKN TIVLDPNVQK RRWEKLIYNS VFNVICALVQ VDNNRIQMNI GNDSLIRPAM
     YEVIAIAKSE GIECDEAFVE KYVHIGDGLF YTPSMAIDVQ KGQLMELEII LGNPMRIAEK
     NKVPTPVLSV LYPLLKVVQF RLKEQRGLIT IDKSDFKGQN SDDYPGILQD KYINKH
//