ID A0A368VVN4_9ACTN Unreviewed; 587 AA.
AC A0A368VVN4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 28-JAN-2026, entry version 30.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=DFQ14_102459 {ECO:0000313|EMBL:RCW46156.1};
OS Halopolyspora algeriensis.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes;
OC Actinomycetes incertae sedis; Halopolyspora.
OX NCBI_TaxID=1500506 {ECO:0000313|EMBL:RCW46156.1, ECO:0000313|Proteomes:UP000253495};
RN [1] {ECO:0000313|EMBL:RCW46156.1, ECO:0000313|Proteomes:UP000253495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 8575 {ECO:0000313|EMBL:RCW46156.1,
RC ECO:0000313|Proteomes:UP000253495};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCW46156.1}.
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DR EMBL; QPJC01000002; RCW46156.1; -; Genomic_DNA.
DR RefSeq; WP_114451954.1; NZ_QPJC01000002.1.
DR AlphaFoldDB; A0A368VVN4; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000253495; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:RCW46156.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000253495}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 332..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 63247 MW; 317FA1CFD7324E89 CRC64;
MHVIATAGHV DHGKSTLIRS LTGMEPDRWS EERRRGMTID LGFAWTTTAD GTTLAFVDVP
GHERFVPNML AGIGSVPAVM FVVAADEGWM PQSSEHLQAL HALGVRHGIL VVTRSDLADP
EPAAEQARHH LRDTSLAQLP VIRVSGATGD GVAELRSALH TLVDGLARPD HHADPRLWVD
RAFTVHGAGT VVTGTLAAGT LRTGQQLLLH PHGHEVTVRG MQCLGTEASS AGAVARVALN
LRGTRLENVR RGDVLLAPGR WLSTDVVDVR LRGTESRELP RQLMLHMGSA AVSARVRPLG
PDTARLSLRT PLPLRIGDRA LLRDPGSHRV PAGVTMLDVQ PPPLQRRGAA GHRARELEEI
GDRADGAAEL RRRRVVRTDD LIAMGATPPS GAPQGGGWLL DPAHRDTLAA RLIDLLSEYR
RKYPLEDGMP VEAVRRALEL PDSALLPSVL RAITSADVTT RDGRVCRGPA PLPEAVRNAL
STLHSTLTDK PFVAPTAEEL DELGLGSKEI AAAVRAGELL KLDQGIVLLP DALEQAVQRL
SQLPAPFTAS QAKKALATTR RVAIPLLETL AHRRYTERLA DGSHRLR
//
