ID A0A369S8E3_9METZ Unreviewed; 4905 AA.
AC A0A369S8E3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 02-APR-2025, entry version 29.
DE SubName: Full=Dynein-1-beta heavy chain, flagellar inner arm I1 complex {ECO:0000313|EMBL:RDD42782.1};
GN ORFNames=TrispH2_004762 {ECO:0000313|EMBL:RDD42782.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD42782.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD42782.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD42782.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD42782.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD42782.1}.
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DR EMBL; NOWV01000048; RDD42782.1; -; Genomic_DNA.
DR STRING; 287889.A0A369S8E3; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF36; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 3.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000313|EMBL:RDD42782.1};
KW Cilium {ECO:0000313|EMBL:RDD42782.1};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Flagellum {ECO:0000313|EMBL:RDD42782.1};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 1036..1498
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1694..1808
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1940..2024
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2106..2205
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2522..2583
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 3048..3261
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3341..3670
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3854..4038
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 4325..4435
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4478..4591
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4638..4869
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 146..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2055..2093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2226..2247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2482..2514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3340..3402
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3578..3615
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4032..4059
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 146..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2060..2093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2226..2244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2482..2498
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2499..2514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4905 AA; 563028 MW; 570665ADE2D08C1F CRC64;
METSKSPIEH STALKFISDY KKAVDDETVD SFQYNASALI DLAKDKQELF EEDIAIIREH
LTRLFVTVLG EESNEWQWSR LYEVLESLQP WSSSIISHQI TYYINRINRH IITNPSTPCA
TSISDIIKAF NSSKDTTSNN KITSAVNGSK QTENVTENAS KSPRLNKQIP ARNPLKEEDN
PYVLKIRDNQ SYIPDDELKF RDINESLPVV LQEISQRESA WPNPVGATIA AMKLNLPDHV
KETGEKADSI DRGSKDNLIS ISISPRTKKI LKDSRAEELK INTEIKTGWD ILKLFAAGRH
TGRLQFAYLN FDDSTKDFRP YDLVAVPKNK INPEHFVMSC YGVLHVYPDQ SAESLTLDEW
QKEATIFNAI TKIFFFRNFL LRKLFLRWRR NSKYSQFYKT RQIISRDLLL NNNSFYSAIS
QISSLLVDLE TIEFLPLDEH TCFTLADFVE FCQRTREKAD KFIRKFFTYS QKIMDKTFES
SLDRLKHYEA LCKKKQPITK ESLYIMKQKA DKRQQDLEDA KNEVRRLSHL ASLIDYLTIE
SLVKMSRANI TKFVTKTLSD ESTRRDALFK ADLVFNSEDQ LMLQPFQRHF RKIIASMLND
IPSILCEMIK TSQSPDEPLV LQTLTNSSSF MQSPLPRISS VMNQAQDTTE VNDLEESQNQ
QNTNAKRGVA FAPTPSNQGK EFMRLPTPTK SPSIQFSDSK RDLSTREEYV VKPNYNIEVQ
GHSIIAQHTP LSKRNLEEKL HLDILIQEYN QKQSLLVEED LADIDQFCAK YEWLCEIHAF
VRQWGNNQMN ELNKVNPQVF KEQFQIISQW IERVQEVPDS FITSNKLFNI HCKGIEYALL
PRLKQIFKNL DNLISEKYHT LAVGFIRGID SLTTEMYERK FDIEKFAKFV HRVSQTNESQ
NQLEDDLNNI KFYYEVIRKH CHQPTTEESH LLSKLNSCWR IFSVSLLDAV EFVDSEKPIM
IEGLEEKIKA LAADAEDIGK DATSGIFLDP DQSPSHALTL MRDLRNEFQD IRTSLLNLSK
WRESITGRPY DFSRLTAILK NIDIRQEMWK YIEVSEGRIR DWMNTSFYKL DVTKLIHKVN
EWKNASVQLR NQLPIGDRVL DYWKKSLVDI ERHTPFLAKL STKSLKVRHW KDIFIGIGQP
YDSTWLFTTK ELLSFDLELH TSLINSVVAR ADAEFALEGS FQQICKVWED KKLQLTKHIP
IVQVSNVNQT PMSTDSNVNE IAKQDSRMDD DALVLMGVEE LKVQLEDHQI TLRGMLVSSH
LADLRYQVEA WSTMLQQLNE IIDSWSNCQQ KWLLLYNVFQ RKRIKTDLSK QYQEFEKINS
GYKDFLRSVV ENPKVLNLVN RRRSQKAHKD VHGENLLQLL FNYSDTQDQI IKHLYFLLEE
ARNEFPRFYF ISNHQLLDIM SYADNPSALA QFVNHCFPGI LSLKLILPEQ TISVMRNTTN
EINAAFNAHL LQVSALEGNL DEVIELTTRI KAESQPHKWF AAVETGMKES LAIILQDCLH
SRLDGMKAPD DISSLNKLHY VIESKLTGQL QYWRYGDNII SYFMRYPSQC IELVEAIVWA
QCVLLTCSRV TPVRFTDIKE WLISNINFLV DNLNTGIKYR VAEHAQKRIT LLITSLITRA
VYHRDVMDRL NEFASYSPRS FEWQSTLRYD IKYMKESISP KQRYKFANQS ELSQMFNLMH
IDCNLNIVGR QIQYGYEYSG PYSRLVLTPL TERCFIAMAS AISNYQCGAI TGSAVFGKAE
TIRELGLSTA HHSVIFSCSS FMDISNFSNL LTGVLKSGSW LNLLRVDLLP TNVLSVLSHY
LNQLRDGLKC LDLSQSSQYS QRGKTVYQLD YDFNEGLEEI LIPIYSRRNS INTLHSFISK
KEDSSHHQRS TPLLHQLQRR NSTGSLSGSI QTAHRPMKKQ HSNFEYHFQH RSANDMKRSA
IDYLKTTCNS TPPKVLPLGS ICFQQQLIQA NPHLGCFVTM EAHQILGSRL PDNFRKLLRP
MCIIQPDIRP ITEVLLLCGG FNQITYLSSK IEKLWKMAET QLTSSLSLKL LREILNCSRQ
KLEEIKIQQL IQSDLDQSSP TNPDNIKYSS PAPSETLTTR SASPISSTLN RSPVMSDQES
NISIIMEESA IVYGIQTIAK AQLLINDNII IKRLAEDVFP VHRKIENIEN LSADDSTLIT
AVKEQLKLEY LEPTPTTINK IISLNMSIKN HLGVILFGPS GSGKSTSYEM LSRVLNVLHT
EQLYQQSPSN RPVTKGGSKT NYIGQDNEPT KAINSEELTT VSTGPQPTFP RVETIITYVK
SLSNKQLFGS TDSKDGWQDG LVSKLFRDAA QSQRQQATQR SYSSVSKWFI FDGVMDTSWT
ELFIKLLDRS TITLPSSEKI TLPSSCSLLF ELCDLTDASP SIVTRCSLVH NGSDGVSWKH
LISKWRQNSI GNWHISDHDM DLLASLIENI MEPAIEFFRS HRSKTMNDFH SVGVVEGIHE
IHSLLTILSA LFDRYMSREG LSTADSTTTD STKSFSRDIG SSRQSTPSSP LRTRYSGSSL
AVVNLLAYAY IWSLGGNLNE ELHQQFDLLV RKCLSSYGIQ LPKMGLVFDY LYDKRTSQLV
QWESVYSSSQ RMIPSSYFTT CNLEKYFHLL EILVASGSSV VLVGESGVGK GSMIQNRIQS
RHSYTKITIT PNLQVDELLD TINNKLNSFE RFQIGRQNNP QQTGSRKLLF YLDDLSTAYN
DPTANAQPIC EILRQVISIG GTFHRHRLNF RNMRHIHFII TATDPYTAGM GGGVSRYCIS
SRFLRLFPVI RLRNSSHEQL TDLFNTSINC WLEQIVPHPL ACSNELSNAL ATATVELYTK
IKANLKPTPL HPQYVFTLHN LHRVLSRMFS VSVNPRSVRR RSFVQFTNND KTTDRKALSS
VSQDPNLPVI RTTIRLWCHE VSREFSDRLT NENDQHLYEE ELRQIVIKHF CSRRSPTTNL
PSKATSNSLT IPKTPVKKPM LLTVNLPEAL STPNSSNDPL IQREALFSSR EKLRDIVFTK
YFMPNSDGRF NRGDFNRYYT ECSLGEFRIG LEQCLATYNE ETSTQRIEFA FFPEAVEHIR
HAVNALSIPG SHCLMIGVPG SGKSTIVKLA TFAANCEVLK IDSSMIDQEI SDTIKIACLS
AGMYEKRTVL LVSDTLPEKW MYYISCSLMT DGIIPGLITP SELMNIWSQK ATGIGTRRID
NPDVVYDQFT NLVRKHLHVI VSLTYRGGAE EDFSYAERSL LTMLNKFPQM LINSSCVDIY
KPLSIASLQI FAQEWLENNF IPLIDTNVDH DYDLVSRLDK ISNAIARIYA ISRDTAIQLS
IKDSSYDEMF TLDTYNEYLV LIRTIACDIL DKEKEITKIY ESGLKKLNEV ECEVEMIENR
LSQLKPVLQQ NQRISQQWQA AVVQEKEDYV KARDECRDTE KEIVRIGDII RELKEDAHTE
LNKVLPLFET ALKALKSLKP QDVDELRTYR DPPDAVVHVM NAICVLFDRE RSWFESKRLL
YRENFFLDLE LYDKDNLSDS KHKELRRFYN NPQMKPEVVG QSSAAACSLC RWIRALYEYS
TVYRKLTPRR QFLQEESKRL IKVETLLGDR RLTCEGIRRK LESKLQSHKD CIRQVKETEK
RIQESNDRID SATTLIESLR LHTGDWKKKV ADSKENINSC FGDALVAAAC VCFHGPFSME
TRLQLQQLWI DACQSGGQNA ATTENNSLQG SIPVRKNFNL AEILSSEEEQ YIWKRNGLPT
ESIDINNALI LRTASDHRFR SWPLVIDPDD ISLEWVKALM SSETKLGQYA KRRLMMNPML
NYKLNDIVHD MTFTSSTTTS PDISEDKIID LPSFGSMHGI FKPRTLTVSS GMNTSPSLIG
VSSVLPEQIE TSMMIQSQER SVMVINIDSD GIQERVLEAV QNGYVLMIRH FERVVNDDSL
ISLIQRNIVF DQYDHNKMKM RIAGELIDFN PNFRLVLISS FPLAVIRSSL SVLPFANLAI
YNIAASDQGM LTELFNMTIS LERPEYNGQL RSLDADVHHH RQQLDVEMGR ILKKVSNYEN
LILDDETLVE ELQKTRQNYD LYQERLQEAL KQRNNLIDRQ QAFLPVATRG AILYKIMSNM
ISLSSLYHFR LGWFLDTFTS AISECKDSKI IGGSPDARAA ELCNFLTLSI CKRLSWSLLK
KHSFLCISMV TISILRQQSI NQQITNEEYV LFANGPKTQL SLRNSSEFTI NVDIPAWISR
EAWISLKQIP NYEPIVSSFL TLRNQWNEYF SSNPSLISTT PGYPTLSLSF FQKALLLRLV
RPELTTKILE ELILYTLGTA YSVMPPYNLD ELVKSSKVHT PIMCFTENQH AEDDNKNMDN
TALSIDALKE IMSCGARFSM NGRIVHLSLG EPDCISEAIR IIKLALRTGW WVVLQNCHLV
QYWSTALKNL IQRIIYSKYS PQKWNIHQDF RLWFTTSINR GYEMPALFSQ HSIKVAIEQS
VKLQDILFTS YHQSVNFLKV GLQRQHYKPL QAHAKSDFLW LLCFIHTILL KRQTFGRFAS
IHNYQWSQED LLAAIDAVVC CINDDIASLT SLITSVFYGG AVISEFDLNT TRSVITLAIK
DLLPLVKDRP FLSYQMSNKD WKDVLSHLDQ LVYIGLSEKV DEAVSANFGM AILHNMKLSL
GDEKLVSIQY DEYLQLLSLL SIRIPEEIKV EDIDAQLDIG HLANGCLLRF LRDDANRYNK
VIRMIRKEIF QLREATNGNY SLTPRLEKIC SNLRNLIVPT HWYPYLPTHL PFNQWLEDLS
RKVATLTSYI KTSQESDLND CDLRIFYQPA GFLDSLLQDY NGLVKAGVLE IDFEVKIFND
SEKKCDHGIH LLGLQLHNAA WDFTKCCITQ VKEAQATCPL PIIWLRPIKL SNKVKKSSYP
TYSCPVLHSY YQDVDKNCMI RLSLATEIEV GILYLKRVAI SVMDR
//
