ID A0A370TND8_9HELO Unreviewed; 709 AA.
AC A0A370TND8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 02-APR-2025, entry version 21.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=BP5553_04465 {ECO:0000313|EMBL:RDL37032.1};
OS Venustampulla echinocandica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Pleuroascaceae; Venustampulla.
OX NCBI_TaxID=2656787 {ECO:0000313|EMBL:RDL37032.1, ECO:0000313|Proteomes:UP000254866};
RN [1] {ECO:0000313|EMBL:RDL37032.1, ECO:0000313|Proteomes:UP000254866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BP 5553 {ECO:0000313|EMBL:RDL37032.1,
RC ECO:0000313|Proteomes:UP000254866};
RX PubMed=30018880; DOI=10.5598/imafungus.2018.09.01.13;
RA Wingfield B.D., Bills G.F., Dong Y., Huang W., Nel W.J.,
RA Swalarsk-Parry B.S., Vaghefi N., Wilken P.M., An Z., de Beer Z.W.,
RA De Vos L., Chen L., Duong T.A., Gao Y., Hammerbacher A., Kikkert J.R.,
RA Li Y., Li H., Li K., Li Q., Liu X., Ma X., Naidoo K., Pethybridge S.J.,
RA Sun J., Steenkamp E.T., van der Nest M.A., van Wyk S., Wingfield M.J.,
RA Xiong C., Yue Q., Zhang X.;
RT "IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium,
RT Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis
RT basicola), Ceratocystis smalleyi, two Cercospora beticola strains,
RT Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina,
RT and Morchella septimelata.";
RL IMA Fungus 9:199-223(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDL37032.1}.
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DR EMBL; NPIC01000003; RDL37032.1; -; Genomic_DNA.
DR RefSeq; XP_031869688.1; XM_032013088.1.
DR AlphaFoldDB; A0A370TND8; -.
DR STRING; 2656787.A0A370TND8; -.
DR GeneID; 43597314; -.
DR OrthoDB; 5302359at2759; -.
DR Proteomes; UP000254866; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708:SF25; PROTEIN PAM1-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000254866}.
FT DOMAIN 13..120
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 154..277
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
FT REGION 284..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..339
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..459
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..685
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 76504 MW; 4B580D5DE6595C31 CRC64;
MASRSSRSSY FGNERFKPRQ VVRAPEDASQ TKGGAFDYVL LCVKALPDVY DLAAVIESVV
TPQHTCILVN TTHALGVEAH IESRFPSNVV LSLVCGAEIT QLAPSEFEHK GSTEIWVGPA
NINPSMPGTI QNDMAEALAM TLSSGQVDCH VSNNIRQQQY ERMIGPIAFQ PLSVIFETPS
HSALLEKVGV KSLISDIFDE LLNIAQAQDC RFPADFKAKV MGEMVRPTEA NSIMYQDFAA
RRPMEIETYL GSPIKLAQSV GVQVPRIDTL YTILHNLNIV NQQRKDIPAP SPGPNGAPAR
LSSLPPGRAM MNGPPNGMGP NRGRGRTPSM NGPPMGMRRG PPPMSGGPAN VYGRAVNGNG
YPGPRNQSRR GSLDGNDLEE FSHLVLYDDI PESGESNYGG DGPEMGMRER ELMLRQRELA
LREQEMRMRS RGGPGPRRSA APSIRNGGYD DDDDEDGFDP QDGPPPPVID PDNFDMMSVT
SRRNRKAPSA SQFRKNPEFG DAPPRRGGGF MRPGYLRNRA SAQMMSQVPG LHDSLMDDPL
MGYSSNRYGT VDRQQMGKES RNNSLTSVRL DELQYGGPPH PNGAGPYPRR ASQSPGNPYS
PQMGRGGRPS PPNGYGPPMN GRPSPPGGMM RQPVPRHPPG HGNSVAPQQV EQYAGVSALH
PPKGPMNVRS LTGSASASAG SGDSANIDSE PSAHSSQSSL GPRPPTGVR
//
