ID A0A370TSU4_9HELO Unreviewed; 720 AA.
AC A0A370TSU4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 02-APR-2025, entry version 27.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=BP5553_02942 {ECO:0000313|EMBL:RDL38602.1};
OS Venustampulla echinocandica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Pleuroascaceae; Venustampulla.
OX NCBI_TaxID=2656787 {ECO:0000313|EMBL:RDL38602.1, ECO:0000313|Proteomes:UP000254866};
RN [1] {ECO:0000313|EMBL:RDL38602.1, ECO:0000313|Proteomes:UP000254866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BP 5553 {ECO:0000313|EMBL:RDL38602.1,
RC ECO:0000313|Proteomes:UP000254866};
RX PubMed=30018880; DOI=10.5598/imafungus.2018.09.01.13;
RA Wingfield B.D., Bills G.F., Dong Y., Huang W., Nel W.J.,
RA Swalarsk-Parry B.S., Vaghefi N., Wilken P.M., An Z., de Beer Z.W.,
RA De Vos L., Chen L., Duong T.A., Gao Y., Hammerbacher A., Kikkert J.R.,
RA Li Y., Li H., Li K., Li Q., Liu X., Ma X., Naidoo K., Pethybridge S.J.,
RA Sun J., Steenkamp E.T., van der Nest M.A., van Wyk S., Wingfield M.J.,
RA Xiong C., Yue Q., Zhang X.;
RT "IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium,
RT Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis
RT basicola), Ceratocystis smalleyi, two Cercospora beticola strains,
RT Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina,
RT and Morchella septimelata.";
RL IMA Fungus 9:199-223(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDL38602.1}.
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DR EMBL; NPIC01000002; RDL38602.1; -; Genomic_DNA.
DR RefSeq; XP_031871258.1; XM_032011565.1.
DR AlphaFoldDB; A0A370TSU4; -.
DR STRING; 2656787.A0A370TSU4; -.
DR GeneID; 43595791; -.
DR OrthoDB; 9977870at2759; -.
DR Proteomes; UP000254866; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20335; BRcat_RBR; 1.
DR CDD; cd22584; Rcat_RBR_unk; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM00647; IBR; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51873; TRIAD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000254866};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 253..445
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 456..561
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 116..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..183
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 81771 MW; DE2F2DC3D216CEB4 CRC64;
MAMVAIMPGN WPKDGPEEED MSDEPFLPRF SSSMMTAKPS PPAHDELFID TNQSNEASSP
SYLLFEPVVS SVSETEPIDN WRRYDPPREL LDFQDGTSTD IRSLLEPSIE RIRDRHRADV
EMRTAAARRE KPLGRAGRAS AKPRRDISMS GALDPSIFTH SPRSSQGSGA SLSSGDSGYG
SRSPAANSPD HASSRVEKKF LSAISSRFKL KRTDKTPNHP ATPNQNGSAL VLPTMQEPPG
QVDVGNDAIP VPLTGECVSC LDDFATTNLI KLTCHSYCAD CFQRLINNAL ESETHWPVKC
CLTKIPSSTI EPHLDRKTQK KYHGREAEWS IPVGNRIYCA HPNCGTWISP EGIKRESNRA
KCPKCSRKTC TSCRGISHTG TECPHDPALI ATINLADQEG WKRCYSCHAL VEHTQGCRHM
TCRCNAQFCY ICGLRWRTCS CTNDQLADIQ GQAAIRRNEE AARTALQTAA AEEERRALWL
VAEFERREAE MEAAEAEARR VQEEEEQRRQ EEERIAAVNV RFLHLSTELE SLHDVQHVRI
AERYDLEQET LQKERENALE TLSIRHPQET QVLALESQTK ISDMEHKLEM EYHGLLAEEQ
RIEHKYVDEL RAYWKGKPGG EYKVRAARDE LRRDQDIEYK SWENYRKSKL QALAEGERKQ
MDTLRAKQRS EVRTVEGRAQ IDEVEWKRKR AAEAKWVEVV INERTEILQG LERDEYAQGG
//
