ID A0A372G0Z1_9ACTN Unreviewed; 600 AA.
AC A0A372G0Z1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 28-JAN-2026, entry version 30.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:RFS46653.1};
GN ORFNames=D0Q02_09400 {ECO:0000313|EMBL:RFS46653.1};
OS Micromonospora craniellae.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=2294034 {ECO:0000313|EMBL:RFS46653.1, ECO:0000313|Proteomes:UP000262621};
RN [1] {ECO:0000313|EMBL:RFS46653.1, ECO:0000313|Proteomes:UP000262621}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LHW63014 {ECO:0000313|EMBL:RFS46653.1,
RC ECO:0000313|Proteomes:UP000262621};
RA Li L., Lin H.W.;
RT "Verrucosispora craniellae sp. nov., isolated from a marine sponge in the
RT South China Sea.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFS46653.1}.
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DR EMBL; QVFU01000007; RFS46653.1; -; Genomic_DNA.
DR RefSeq; WP_117227595.1; NZ_CP061725.1.
DR AlphaFoldDB; A0A372G0Z1; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000262621; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:RFS46653.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000262621}.
FT DOMAIN 1..168
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 600 AA; 63090 MW; E31DF813E473A420 CRC64;
MLVVATAGHV DHGKSTLVRA LTGMEPDRWA EERRRGMTID LGFAWTTLAS GTTVAFVDVP
GHERFVPNML AGVGPVPAAA VVVAADEGWM PQSAEHLAAL DALGVAYGLL VVTRADLADP
GPALARARAE LAVTSLRGVE AVVVSGVTGV GLPDLRAALD RLAARVPSAD RTAPVRLWVD
RSFTVRGSGT VVTGTLGAGR LRVGDELELA GTGEKVRVRG LHRLGEARDA VDPVARVAVN
LRGVPRDRVA RGDALLTPGR FRASELVDVR LAGDAVTALP ATLTLHVGAA AVPARVRPLG
GDTLRLRLGR PVPLLVGDRA LLRDPGRHHV AGGVTVLDVL PPLLRRRGAA AARAAVLATL
DGRPDLAGEL RRRGLVRAGD LVRAGVPVPV APVAGDWLAD PDHWRRLADR LADAVARYTR
EHPLEPGAPV EVLRRQLDLP DRVLVEALVR APLRLTAGRV GTAGADPLPE SVARAVALVR
DDYAAYPFRA PDADRLAAVG LGVREIGAAV RAGALLRLTG NVLLLPGAPQ QAVRVLAGLP
QPFTLSAARQ AWDTTRRVAV PLLELLDRQG RTRRLPDDAR VVVDADCVDP PAAGRPGRLP
//
