ID A0A376GZS2_ENTGA Unreviewed; 368 AA.
AC A0A376GZS2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 28-JAN-2026, entry version 29.
DE SubName: Full=Amidohydrolase/deacetylase family metallohydrolase {ECO:0000313|EMBL:MXS27402.1};
DE SubName: Full=Metal-dependent hydrolase {ECO:0000313|EMBL:STD83546.1};
DE EC=3.5.2.3 {ECO:0000313|EMBL:MXS27402.1, ECO:0000313|EMBL:STD83546.1};
GN ORFNames=GTI89_15185 {ECO:0000313|EMBL:MXS27402.1}, NCTC12360_02013
GN {ECO:0000313|EMBL:STD83546.1};
OS Enterococcus gallinarum.
OC Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1353 {ECO:0000313|EMBL:STD83546.1, ECO:0000313|Proteomes:UP000254807};
RN [1] {ECO:0000313|EMBL:STD83546.1, ECO:0000313|Proteomes:UP000254807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12360 {ECO:0000313|EMBL:STD83546.1,
RC ECO:0000313|Proteomes:UP000254807};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MXS27402.1, ECO:0000313|Proteomes:UP000439965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E3404 {ECO:0000313|EMBL:MXS27402.1,
RC ECO:0000313|Proteomes:UP000439965};
RA Liang G., Bushman F.;
RT "Step-wise assembly of the neonatal virome modulated by breast feeding.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; WVTI01000021; MXS27402.1; -; Genomic_DNA.
DR EMBL; UFYW01000001; STD83546.1; -; Genomic_DNA.
DR RefSeq; WP_003128947.1; NZ_CP116510.1.
DR AlphaFoldDB; A0A376GZS2; -.
DR OrthoDB; 9796020at2; -.
DR Proteomes; UP000254807; Unassembled WGS sequence.
DR Proteomes; UP000439965; Unassembled WGS sequence.
DR GO; GO:0019213; F:deacetylase activity; IEA:InterPro.
DR GO; GO:0004151; F:dihydroorotase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01307; Met_dep_hydrolase_B; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR InterPro; IPR020043; Deacetylase_Atu3266-like.
DR InterPro; IPR047601; EF_0837-like.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR03583; EF_0837; 1.
DR NCBIfam; NF006689; PRK09237.1; 1.
DR PANTHER; PTHR42717; DIHYDROOROTASE-RELATED; 1.
DR PANTHER; PTHR42717:SF1; IMIDAZOLONEPROPIONASE AND RELATED AMIDOHYDROLASES; 1.
DR Pfam; PF22647; EF_0837-like_N; 1.
DR PIRSF; PIRSF039004; ADE_EF_0837; 1.
DR SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:STD83546.1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR039004-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000254807};
KW Zinc {ECO:0000256|PIRSR:PIRSR039004-1}.
FT BINDING 57
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR039004-1"
FT BINDING 59
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR039004-1"
FT BINDING 151
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /note="via carbamate group"
FT /evidence="ECO:0000256|PIRSR:PIRSR039004-1"
FT BINDING 151
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /note="via carbamate group"
FT /evidence="ECO:0000256|PIRSR:PIRSR039004-1"
FT BINDING 185
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR039004-1"
FT BINDING 208
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR039004-1"
FT BINDING 269
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR039004-1"
FT SITE 153
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR039004-3"
FT MOD_RES 151
FT /note="N6-carboxylysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR039004-2"
SQ SEQUENCE 368 AA; 40689 MW; 615FB917AA7619F8 CRC64;
MFDTLIKNGK LIDGSKVEVA LEKGIIKAVA SEINEPAREV IDLSGNSYLS AGWIDDHVHC
YEKMNLYYDY PDQIGVQKGV TTVIDAGTTG AENIRDFYQL TKSVKTNVYA LMNISKWGIV
EQDELADLTK IQENLVRSAL AELPEFIVGI KARMSKTVVG ENGITPLELA KKIQSENNDL
PLMVHIGSAP PELEEVLTRM EKGDVLTHCF NGKPNGILDQ ATDQIKDFVW DAYKKGVVFD
IGHGTDSFNF HVAETALKAG LKANSISTDI YIRNRTNGPV FDLATTLEKL RVVGYSWEEI
IEKVTAVPAK NFHLAKKGQL TVGFDADLTI FEIVENEKEL KDSNGVTRIA KEQIVPVQTI
IGGVIYDN
//
