ID A0A381JAK9_9CLOT Unreviewed; 597 AA.
AC A0A381JAK9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 18-JUN-2025, entry version 23.
DE RecName: Full=GTPase HflX {ECO:0000256|HAMAP-Rule:MF_00900};
DE AltName: Full=GTP-binding protein HflX {ECO:0000256|HAMAP-Rule:MF_00900};
GN Name=hflX {ECO:0000256|HAMAP-Rule:MF_00900,
GN ECO:0000313|EMBL:SUY47412.1};
GN ORFNames=NCTC9836_01743 {ECO:0000313|EMBL:SUY47412.1};
OS Clostridium putrefaciens.
OC Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=99675 {ECO:0000313|EMBL:SUY47412.1, ECO:0000313|Proteomes:UP000254664};
RN [1] {ECO:0000313|EMBL:SUY47412.1, ECO:0000313|Proteomes:UP000254664}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC9836 {ECO:0000313|EMBL:SUY47412.1,
RC ECO:0000313|Proteomes:UP000254664};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase that associates with the 50S ribosomal subunit and may
CC have a role during protein synthesis or ribosome biogenesis.
CC {ECO:0000256|HAMAP-Rule:MF_00900}.
CC -!- SUBUNIT: Monomer. Associates with the 50S ribosomal subunit.
CC {ECO:0000256|HAMAP-Rule:MF_00900}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00900}.
CC Note=May associate with membranes. {ECO:0000256|HAMAP-Rule:MF_00900}.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. HflX GTPase family. {ECO:0000256|HAMAP-Rule:MF_00900}.
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DR EMBL; UFWZ01000001; SUY47412.1; -; Genomic_DNA.
DR RefSeq; WP_115641371.1; NZ_UFWZ01000001.1.
DR AlphaFoldDB; A0A381JAK9; -.
DR OrthoDB; 9812272at2; -.
DR Proteomes; UP000254664; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR CDD; cd01878; HflX; 1.
DR FunFam; 3.40.50.11060:FF:000001; GTPase HflX; 1.
DR Gene3D; 6.10.250.2860; -; 1.
DR Gene3D; 3.40.50.11060; GTPase HflX, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00900; GTPase_HflX; 1.
DR InterPro; IPR030394; G_HFLX_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR032305; GTP-bd_M.
DR InterPro; IPR016496; GTPase_HflX.
DR InterPro; IPR025121; GTPase_HflX_N.
DR InterPro; IPR042108; GTPase_HflX_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03156; GTP_HflX; 1.
DR PANTHER; PTHR10229:SF0; GTP-BINDING PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10229; GTP-BINDING PROTEIN HFLX; 1.
DR Pfam; PF16360; GTP-bdg_M; 1.
DR Pfam; PF13167; GTP-bdg_N; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51705; G_HFLX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00900};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP-
KW Rule:MF_00900}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00900}; Reference proteome {ECO:0000313|Proteomes:UP000254664}.
FT DOMAIN 364..542
FT /note="Hflx-type G"
FT /evidence="ECO:0000259|PROSITE:PS51705"
SQ SEQUENCE 597 AA; 67055 MW; 8345126774C179A1 CRC64;
MIYGSIEGVK KSIIDSLEDI NEMTLPKYML FTEEILNILV DSSSRLGREI SVAIDRKGKV
VGVAIGDSST VEIPMINIKE KKLSGVRIIH THPNGNSRLS AIDNSALLKL KLDCIVAIGI
FNEKLTDISV GFCDVKENLL IPELMEGLTL KESLNFDFMD KVKNIETIIE SNEIDEDNGE
KAIIVGSDTE ESLDELGQLA KACDIPVLFS VFQNRSKIDP TYYIGKGKVE EVALLRQGLR
ANVVIFDDEL SGSQVRNLEE VIGCKVIDRT TLILEIFATR AKTKESKIQV ELAQLKYRLS
RLTGLGTILS RTGGGIGTRG PGEKKLETDR RHIRETVYDL TSELSKIKKT RETQREKRNK
QNIPQVSLVG YTNSGKSTLR NALYDMAMPK DSIEKSKVFE ADMLFATLDT TTRAINLLDN
RLITLTDTVG FVRKLPHELV EAFKSTLEEV IYSEILIHVV DSSAEYVDEQ IEAVEDVLSE
LGVEDKSMIL ALNKIDNISK EGLEELINRY KEKYQIVSIS AKENINLELL LETIANKLPN
KLKEVEYVIP YSEQSAVAYL HRNAKIIEST YEDEGTYIKA QVDDEIYNKC RQFIKGI
//
