ID A0A383VHK2_TETOB Unreviewed; 442 AA.
AC A0A383VHK2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 02-APR-2025, entry version 25.
DE RecName: Full=CDC20/Fizzy WD40 domain-containing protein {ECO:0000259|Pfam:PF24807};
GN ORFNames=BQ4739_LOCUS4804 {ECO:0000313|EMBL:SZX64289.1};
OS Tetradesmus obliquus (Green alga) (Acutodesmus obliquus).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Scenedesmaceae; Tetradesmus.
OX NCBI_TaxID=3088 {ECO:0000313|EMBL:SZX64289.1, ECO:0000313|Proteomes:UP000256970};
RN [1] {ECO:0000313|EMBL:SZX64289.1, ECO:0000313|Proteomes:UP000256970}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Cai Z.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. {ECO:0000256|ARBA:ARBA00023425}.
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
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DR EMBL; FNXT01000394; SZX64289.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A383VHK2; -.
DR STRING; 3088.A0A383VHK2; -.
DR Proteomes; UP000256970; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:TreeGrafter.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:InterPro.
DR GO; GO:1990757; F:ubiquitin ligase activator activity; IEA:TreeGrafter.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR056150; WD40_CDC20-Fz.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF8; FI02843P; 1.
DR Pfam; PF24807; WD40_CDC20-Fz; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000256970};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 123..414
FT /note="CDC20/Fizzy WD40"
FT /evidence="ECO:0000259|Pfam:PF24807"
FT REPEAT 176..210
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 254..286
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 383..416
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 47145 MW; 60D9A402C6E4A828 CRC64;
MTLIQGVSTP GSKQHGSPSA AAGSRIFKTP GGQSKRDKEN SSAASDAAGS QASPSKQEFQ
QLLAGALHLT AEQGARVLAF KHKAPAPPPE HANSMASLYS ANLGSAPQRK QHRHIPTTQE
RILDAPDLVD DYYLNLLDWS SGNQLAIALG PTVYLYNAST GTIEELCSCP AEGEYVTSVS
WAADASHLAI GTSSAKVQVW DAARCKQVKE LAGHTNRVSS LAWNNAILSS GGRDALVCNF
DVRLRKNEAR VATLRGHEQE VCGLKWSPNG CQLASGGNDN MLCIWSAGFE QQHCINAHQA
AVRALAWCPF QSNLLASGGG TADRHIRFWN SSTGAQLNAI DTGSQVCSLV WSRHEREILS
SHGYSKNQLC LWRYPSLVKA AELTGHTGRV LHMVPSPDGS SVVTAGADET LRFWRVFGDA
PTKAADKATG AAPIASRTAS IR
//
