ID A0A384CD51_URSMA Unreviewed; 206 AA.
AC A0A384CD51;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 28-JAN-2026, entry version 39.
DE RecName: Full=Protein lin-28 homolog A {ECO:0000256|ARBA:ARBA00041056};
GN Name=LIN28A {ECO:0000313|Ensembl:ENSUMAP00000017132,
GN ECO:0000313|RefSeq:XP_008692783.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008692783.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000017132}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008692783.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008692783.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}. Cytoplasm, Stress granule
CC {ECO:0000256|ARBA:ARBA00004210}. Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Rough endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004427}.
CC -!- SIMILARITY: Belongs to the lin-28 family.
CC {ECO:0000256|ARBA:ARBA00008840}.
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DR RefSeq; XP_008692783.1; XM_008694561.2.
DR AlphaFoldDB; A0A384CD51; -.
DR STRING; 29073.ENSUMAP00000017132; -.
DR Ensembl; ENSUMAT00000020249.1; ENSUMAP00000017132.1; ENSUMAG00000012579.1.
DR GeneID; 103666516; -.
DR KEGG; umr:103666516; -.
DR CTD; 79727; -.
DR GeneTree; ENSGT00940000153295; -.
DR OMA; NEPQPLH; -.
DR OrthoDB; 422005at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0002151; F:G-quadruplex RNA binding; IEA:Ensembl.
DR GO; GO:0035198; F:miRNA binding; IEA:Ensembl.
DR GO; GO:0070883; F:pre-miRNA binding; IEA:Ensembl.
DR GO; GO:0140517; F:protein-RNA adaptor activity; IEA:Ensembl.
DR GO; GO:1990825; F:sequence-specific mRNA binding; IEA:Ensembl.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0007281; P:germ cell development; IEA:Ensembl.
DR GO; GO:0010587; P:miRNA catabolic process; IEA:Ensembl.
DR GO; GO:0045686; P:negative regulation of glial cell differentiation; IEA:Ensembl.
DR GO; GO:2000632; P:negative regulation of pre-miRNA processing; IEA:Ensembl.
DR GO; GO:0017148; P:negative regulation of translation; IEA:Ensembl.
DR GO; GO:1901724; P:positive regulation of cell proliferation involved in kidney development; IEA:Ensembl.
DR GO; GO:2000767; P:positive regulation of cytoplasmic translation; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:Ensembl.
DR GO; GO:0031054; P:pre-miRNA processing; IEA:Ensembl.
DR GO; GO:0031123; P:RNA 3'-end processing; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
DR CDD; cd04458; CSP_CDS; 1.
DR FunFam; 4.10.60.10:FF:000007; Protein lin-28 homolog A; 1.
DR FunFam; 2.40.50.140:FF:000087; Protein lin-28 homolog B; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR002059; CSP_DNA-bd.
DR InterPro; IPR051373; Lin-28_RNA-binding.
DR InterPro; IPR054081; Lin-28A-like_Znf-CCHC_2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR46109; PROTEIN LIN-28; 1.
DR PANTHER; PTHR46109:SF2; PROTEIN LIN-28 HOMOLOG A; 1.
DR Pfam; PF00313; CSD; 1.
DR Pfam; PF21890; Lin-28A-like_zf-CCHC_2; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR PRINTS; PR00050; COLDSHOCK.
DR SMART; SM00357; CSP; 1.
DR SMART; SM00343; ZnF_C2HC; 2.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR PROSITE; PS51857; CSD_2; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00047}.
FT DOMAIN 35..107
FT /note="CSD"
FT /evidence="ECO:0000259|PROSITE:PS51857"
FT DOMAIN 134..149
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 22453 MW; 835CEB52473FC08C CRC64;
MGSVSNQQFA GGCAKAPEEA PEDAARAAEE PQLLHGAGIC KWFNVRMGFG FLSMTARAGV
ALDPPVDVFV HQSKLHMEGF RSLKEGEAVE FTFKKSAKGL ESIRVTGPGG VFCIGSERRP
KGKNTQKRRS KGDRCYNCGG LDHHAKECKL PPQPKKCHFC QSISHMVASC PLKAQQAPSS
QGKPAYFREE EEEEIHSPAL LPEAQN
//
